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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.
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Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

机译：靶向刻痕以根除胰腺癌干细胞进行癌症治疗。

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摘要

Pancreatic cancer is the most aggressive malignant disease once it is diagnosed and it remains the fourth leading cause of cancer-related death in the U.S.A. Recent data indicates that the Notch signaling pathway plays an important role in the development and progression of pancreatic cancer. Emerging evidence also suggests that the activation of the Notch signaling pathway is mechanistically associated with molecular characteristics of cancer stem cells (CSCs) in pancreatic cancer. Moreover, CSCs are known to be highly drug-resistant, suggesting that targeted inactivation of Notch signaling would be useful for overcoming drug resistance and the elimination of CSCs. This review describes the roles of the Notch signaling pathway in pancreatic cancer with a special emphasis on its novel functions in the regulation of pancreatic CSC. Moreover, the review also proposes that targeting the Notch signaling pathway by natural agents may represent a novel strategy for overcoming drug resistance and the elimination of CSCs, which would be useful for the successful treatment of patients diagnosed with pancreatic cancer.
机译：胰腺癌一经诊断便是最具有侵略性的恶性疾病，它仍然是美国癌症相关死亡的第四大主要原因。最近的数据表明，Notch信号通路在胰腺癌的发生和发展中起着重要作用。新兴证据还表明，Notch信号通路的激活与胰腺癌中癌症干细胞（CSCs）的分子特征在机械上相关。此外，已知CSC具有高度的耐药性，这表明Notch信号的靶向失活将有助于克服耐药性和消除CSC。这篇综述描述了Notch信号通路在胰腺癌中的作用，特别强调了其在调节胰腺CSC中的新功能。此外，该评论还提出，通过天然药物靶向Notch信号通路可能代表克服耐药性和消除CSC的新策略，这对于成功诊断出患有胰腺癌的患者将是有用的。

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