Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product.

Leyssene D; Delmas J; Robin F; Cougnoux A; Gibold L; Bonnet R

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Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product.

机译：CTX-M-9失活突变体与底物哌拉西林及其相应产物的非共价复合物。

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We determined the crystal structure of an inactive Ser70Gly mutant of CTX-M-9 in complex with the bulky penicillin piperacillin at precovalent and posthydrolytic stages in the catalytic process. The structures obtained at high resolution were compared with the corresponding structures for the small penicillin benzylpenicillin and the bulky cephalosporin cefotaxime. The findings highlight the key role of the configuration of the carbon adjacent to the acylamino group of the side chain of beta-lactams in the precovalent recognition of substrates.

机译：我们确定了CTX-M-9的失活Ser70Gly突变体与大青霉素哌拉西林在催化过程中的前共价和水解后复合体的晶体结构。将高分辨率获得的结构与小青霉素苄青霉素和大头孢菌素头孢噻肟的相应结构进行了比较。这些发现突出了在β-内酰胺类侧链的酰基氨基附近的碳构型在底物的共价识别中的关键作用。

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《Antimicrobial agents and chemotherapy.》 |2011年第12期|共6页
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Leyssene D; Delmas J; Robin F; Cougnoux A; Gibold L; Bonnet R;
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正文语种 eng
中图分类治疗学;
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1. Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product. [J] . Leyssene D, Delmas J, Robin F, Antimicrobial agents and chemotherapy. . 2011,第12期

机译：CTX-M-9失活突变体与底物哌拉西林及其相应产物的非共价复合物。
2. The Catalytic Mechanism of Indole-3-glycerol Phosphate Synthase: Crystal Structures of Complexes of the Enzyme from Sulfolobus solfataricus with Substrate Analogue, Substrate, and Product. [J] . Hennig M, Darimont BD, Jansonius JN, Journal of Molecular Biology . 2002,第3期

机译：吲哚-3-甘油磷酸合酶的催化机理：硫磺菌与底物类似物，底物和产物的复合物的晶体结构。
3. Mechanism of action of aspartyl proteases. VII. Noncovalent complexes of HIV-1 aspartic protease with substrate and substrate-like inhibitor [J] . Popov M.E., Kashparov I.V., Rumsh L.D., Биоорганическая химия . 1999,第12期

机译：天冬氨酰蛋白酶的作用机理。七。 HIV-1天冬氨酸蛋白酶与底物和底物样抑制剂的非共价复合物
4. Antibody/Antigen Complexes: Characterization of Immune Complexes using Noncovalent Mass Spectrometry [C] . Cedric Atmanene, Elsa Wagner-Rousset, Nathalie Corvaia, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：抗体/抗原复合物：使用非共价质谱法的免疫复合物的表征
5. Fourier transform ion cyclotron resonance mass spectrometry of biological noncovalent complexes. [D] . Sweeney, Michelle Margaret. 2009

机译：非共价生物复合物的傅立叶变换离子回旋共振质谱。
6. Noncovalent Complexes of an Inactive Mutant of CTX-M-9 with the Substrate Piperacillin and the Corresponding Product [O] . David Leyssene, Julien Delmas, Frédéric Robin, 2011

机译：CTX-M-9失活突变体与底物哌拉西林及其对应产物的非共价复合物
7. Noncovalent Complexes of an Inactive Mutant of CTX-M-9 with the Substrate Piperacillin and the Corresponding Product ▿ [O] . Leyssene, David, Delmas, Julien, Robin, Frédéric, 2011

机译：CTX-M-9失活突变体与底物哌拉西林及其对应产物的非共价复合物 ▿

Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product.

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