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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Analysis of rifapentine for preventive therapy in the Cornell mouse model of latent tuberculosis.
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Analysis of rifapentine for preventive therapy in the Cornell mouse model of latent tuberculosis.

机译：康奈尔潜伏性肺结核模型中利福喷丁预防性治疗的分析。

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Rifapentine is a long-acting rifamycin which may be useful for intermittent drug therapy against tuberculosis. In this study we measured the efficacies of rifapentine-containing intermittent drug regimens for preventive therapy using the Cornell mouse model of latent tuberculosis. We infected groups of mice intravenously with Mycobacterium tuberculosis and then treated them with isoniazid and pyrazinamide for 12 weeks according to the Cornell latency development protocol. After a 4-week interval of no treatment, experimental preventive therapy was administered by esophageal gavage for 12 or 18 weeks. After equilibration and dexamethasone amplification treatment, mouse organs were analyzed by quantitative colony counts to measure the effectiveness of therapy. Our results showed that once-weekly isoniazid plus rifapentine combination therapy for 18 weeks was an effective preventive regimen with sterilizing potency and bacillary load reduction comparable to those of daily isoniazid therapy for 18 weeks. Monotherapy with rifapentine weekly or fortnightly or with rifampin twice weekly for up to 18 weeks did not offer advantages in reducing bacillary load or in sterilizing organs compared to the effects of a placebo. These results with the Cornell mouse model indicate that once-weekly, short-course preventive therapy with isoniazid plus rifapentine is effective and may warrant investigation in humans with latent tuberculosis infection.
机译：利福喷丁是一种长效利福霉素，可用于抗结核的间歇性药物治疗。在这项研究中，我们使用康奈尔潜伏性肺结核小鼠模型测量了含有利福喷丁的间歇性药物治疗方案的预防性治疗效果。我们用结核分枝杆菌静脉内感染了几组小鼠，然后根据康奈尔潜伏期发展方案，用异烟肼和吡嗪酰胺处理了12周。在间隔4周不进行治疗后，通过食管管饲给予实验性预防性治疗12或18周。平衡和地塞米松扩增处理后，通过定量菌落计数分析小鼠器官，以测量治疗效果。我们的结果表明，每周一次异烟肼加利福喷丁联合治疗18周是一种有效的预防方案，与每天异烟肼治疗18周相比，具有杀菌力和减少细菌负荷的效果。与安慰剂相比，每周或每两周使用利福喷汀单药治疗或每周两次用利福平单药治疗长达18周，在减少细菌负荷或对器官进行灭菌方面没有优势。康奈尔（Cornell）小鼠模型的这些结果表明，每周一次异烟肼加利福喷丁的短期预防性治疗是有效的，并且可能需要对患有潜伏性结核感染的人进行研究。

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