• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Survival benefit of stereotactic radiosurgery for metastatic brain tumors in patients with controlled primary lesions and no other distant metastases.
【24h】

Survival benefit of stereotactic radiosurgery for metastatic brain tumors in patients with controlled primary lesions and no other distant metastases.

机译：立体定向放射外科手术对原发灶控制且无其他远处转移的转移性脑肿瘤的生存获益。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The prognosis of patients with metastatic brain tumors has been very poor so far because most patients with metastatic brain tumors had other metastatic lesions and/or active primary lesions. Moreover, if no active lesions existed, local control of conventional radiation therapy was not so good, which also led to the poor prognosis. Thus, we conducted the current study concerning whether survival benefit existed in patients with controlled primary lesions and no other distant metastases, who were treated with stereotactic radiosurgery (SRS), a superior method for local control, for metastatic brain tumors. Seventy-seven patients with 90 metastatic brain tumors were treated with SRS between August 1999 and August 2001, at Tokyo Metropolitan Komagome Hospital, Japan. Of these, 10 patients with 17 metastatic brain tumors had primary lesions controlled and no other distant metastases were included in the current study. The median prescribed isocenter dose was 30 Gy (30-45 Gy) and the median prescribed peripheral dose was 25 Gy (12-30 Gy). One-year and 3-year local control rates were 90.0% and 90.0%, respectively. One-year and 3-year overall survival rates were 88.9% and 51.9%, respectively. These results suggest that SRS for metastatic brain tumors does have a survival benefit in patients with controlled primary lesions and no other distant metastases, which means that we should not treat these patients with palliative intent but pursue longer survival.
机译：到目前为止，转移性脑肿瘤患者的预后一直很差，因为大多数转移性脑肿瘤患者还有其他转移性病变和/或活动性原发性病变。此外，如果不存在活动性病变，则常规放射治疗的局部控制效果不佳，这也导致预后不良。因此，我们进行了一项目前的研究，即在接受控制性原发灶且无其他远处转移的患者中是否存在生存获益，这些患者接受了立体定向放射外科手术（SRS）（一种用于局部控制的优越方法）治疗转移性脑瘤。在1999年8月至2001年8月期间，在日本东京都驹mag医院对77例具有90个转移性脑肿瘤的患者进行了SRS治疗。其中，有17例转移性脑肿瘤的10例患者的原发灶得到了控制，本研究中未包括其他远处转移。中位处方等中心剂量为30 Gy（30-45 Gy），中位处方外周剂量为25 Gy（12-30 Gy）。一年和三年本地控制率分别为90.0％和90.0％。一年和三年的总生存率分别为88.9％和51.9％。这些结果表明，转移性脑肿瘤的SRS在具有受控原发灶且无其他远处转移的患者中确实具有生存优势，这意味着我们不应姑息性治疗这些患者，而应追求更长的生存期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号