...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Antimicrobial agents and chemotherapy. >Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth.
【24h】

Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth.

机译：凝固酶阴性葡萄球菌（Staphylococcus epidermidis）和白色念珠菌的新生儿合并感染模型：预防氟康唑可提高存活率和生长率。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Coagulase-negative staphylococci (CoNS) and Candida are among the most common causes of single infections and coinfections in neonates after 72 h of age. In neonates, coinfection increases the rate of mortality threefold and results in significantly greater morbidity compared to those that result from single infections. In an effort to better understand this phenomenon, we developed the first neonatal animal model of coinfection (with CoNS and Candida) and evaluated its effects on mortality and morbidity and the impact of antifungal prophylaxis with fluconazole. Neonatal Wistar rats were infected with Candida albicans and/or Staphylococcus epidermidis with doses of 2x10(8) and 2x10(6) CFU subcutaneously in different combinations and were monitored for mortality, weight gain, and bacteremia. The in vitro sensitivity of C. albicans to fluconazole was evaluated and the MIC was determined. A subset of rats in these experiments received fluconazole at 10 mg/kg of body weight/dose intraperitoneally starting 24 h before infection for 4 days, and the serum trough levels of fluconazole were measured. Coinfection in the suckling rat significantly increased the rate of mortality compared to that after infection with a single species (P<0.001) and resulted in deaths even at sublethal doses. Coinfection also impaired weight gain significantly in severely infected pups compared to that achieved after infection with a single species (P<0.001). Fluconazole prophylaxis significantly reduced mortality by 30% in the Candida group and 36% in the coinfection group and improved weight gain in this neonatal model of coinfection (P<0.001). We developed a neonatal model of coinfection with Candida and CoNS, observed significantly greater mortality and morbidity with coinfection, and found that fluconazole prophylaxis significantly reduced the rates of both mortality and morbidity. Further research on neonatal coinfection is urgently needed to improve clinical outcomes.
机译：凝固酶阴性葡萄球菌（CoNS）和念珠菌是72小时后新生儿单次感染和合并感染的最常见原因。与单次感染相比，合并感染在新生儿中将死亡率提高了三倍，并导致更高的发病率。为了更好地理解这种现象，我们开发了首个合并感染的新生儿动物模型（与CoNS和念珠菌共存），并评估了其对死亡率和发病率的影响以及氟康唑预防真菌的作用。将新生Wistar大鼠皮下注射2x10（8）和2x10（6）CFU剂量的白色念珠菌和/或表皮葡萄球菌感染，并监测其死亡率，体重增加和菌血症。评价了白色念珠菌对氟康唑的体外敏感性，并确定了MIC。在这些实验中，有一部分大鼠在感染前24小时开始腹膜内接受10 mg / kg体重/剂量的氟康唑，持续4天，并测量了氟康唑的血清谷水平。与单一物种感染后相比，乳鼠共感染显着提高了死亡率（P <0.001），甚至在亚致死剂量下也导致死亡。与感染单一物种后相比，重感染幼犬的共感染还显着损害了体重增加（P <0.001）。预防氟康唑在这种念珠菌感染的新生儿模型中，念珠菌组的死亡率显着降低了30％，合并感染组的死亡率显着降低了36％，体重增加得到改善（P <0.001）。我们开发了念珠菌和CoNS合并感染的新生儿模型，观察到合并感染显着增加了死亡率和发病率，并发现氟康唑的预防显着降低了死亡率和发病率。迫切需要进一步研究新生儿合并感染，以改善临床效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号