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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Antimicrobial activities of gatifloxacin against nosocomial isolates of Stenotrophomonas maltophilia measured by MIC and time-kill studies.
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Antimicrobial activities of gatifloxacin against nosocomial isolates of Stenotrophomonas maltophilia measured by MIC and time-kill studies.

机译：通过MIC和时间杀灭研究测定了加替沙星对嗜麦芽窄食单胞菌医院分离株的抗菌活性。

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摘要

We determined in vitro activities of gatifloxacin and seven other drugs against 100 isolates of Stenotrophomonas maltophilia using the agar gradient diffusion (Etest) method. Percentages of susceptible isolates were as follows: trimethoprim-sulfamethoxazole, 90%; gatifloxacin, 71%; levofloxacin, 57%; ticarcillin-clavulanic acid, 54%; ceftazidime, 49%; ciprofloxacin, 29%; cefepime, 21%; and piperacillin-tazobactam, 20%. Time-kill studies of three isolates indicated that gatifloxacin was bactericidal at times as early as 3 h of incubation when tested at concentrations equivalent to twice the MIC (two isolates) and 4 times the MIC (one isolate).
机译：我们使用琼脂梯度扩散（Etest）方法确定了加替沙星和其他七种药物对100株嗜麦芽窄食单胞菌的体外活性。易感菌株的百分比如下：甲氧苄啶-磺胺甲基恶唑，90％;加替沙星71％;左氧氟沙星57％;替卡西林-克拉维酸54％;头孢他啶49％;环丙沙星29％;头孢吡肟，21％;哌拉西林他唑巴坦占20％。对三种分离株的时间杀灭研究表明，当以等于两倍MIC（两种分离株）和4倍MIC（一种分离株）的浓度进行测试时，加替沙星可在孵育3小时时杀菌。

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