Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.

Swick MC; Morgan Linnell SK; Carlson KM; Zechiedrich L

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Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.

机译：多药外排泵基因acrAB-tolC，mdfA和norE在大肠杆菌临床分离株中的表达随氟喹诺酮和多药耐药性的变化而变化。

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In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux pump transcripts in all fluoroquinolone-susceptible isolates was tolC (highest), then acrA and acrB, and then mdfA and norE. Our findings suggest acrAB overexpression is an indicator of multidrug resistance.

机译：在一项定量研究中，我们通过使用实时PCR测量了大肠杆菌临床分离株中acrA，acrB，tolC，mdfA和norE的表达。 acrA和acrB过表达与氟喹诺酮和多药耐药性密切相关; tolC，mdfA和norE表达没有。在所有对氟喹诺酮敏感的分离株中，外排泵转录本的丰度顺序为tolC（最高），然后是acrA和acrB，然后是mdfA和norE。我们的研究结果表明acrAB过表达是多药耐药性的指标。

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《Antimicrobial agents and chemotherapy.》 |2011年第2期|共4页
作者
Swick MC; Morgan Linnell SK; Carlson KM; Zechiedrich L;
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中图分类治疗学;
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1. Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. [J] . Swick MC, Morgan Linnell SK, Carlson KM, Antimicrobial agents and chemotherapy. . 2011,第2期

机译：多药外排泵基因acrAB-tolC，mdfA和norE在大肠杆菌临床分离株中的表达随氟喹诺酮和多药耐药性的变化而变化。
2. Effect of six fluoroquinolones on the expression of four efflux pumps in the multidrug resistant Escherichia coli isolates [J] . Liu Haixia, Liu Xiaoqiang, Li Yinqian, World Journal of Microbiology & Biotechnology . 2015,第7期

机译：六种氟喹诺酮类药物对多重耐药性大肠杆菌分离物中四个外排泵表达的影响
3. The Escherichia coli cmlA Gene Encodes the Multidrug Efflux Pump Cmr/MdfA and Is Responsible for Isopropyl-β-d-Thiogalactopyranoside Exclusion and Spectinomycin Sensitivity [J] . Chantal Bohn, Philippe Bouloc Journal of bacteriology . 1998,第22期

机译：大肠杆菌cmlA基因编码多药外排泵Cmr / MdfA，并负责异丙基-β-d-硫代吡喃半乳糖苷的排除和壮观霉素的敏感性
4. Enhanced Detection of Multidrug Resistant Escherichia coli from Mastitis through Selection to Cephalosporin Resistance [C] . Clara Locatelli, Antonio Barberio, Valerio Bronzo, Annual Meeting of the National^Mastitis^Council . 2014

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5. Bacterial multidrug efflux pumps: Structure, function, and regulation [D] . Bolla, Jani Reddy. 2014

机译：细菌MultiDrug Efflux泵：结构，功能和调节
6. Expression of Multidrug Efflux Pump Genes acrAB-tolC mdfA and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance [O] . Michelle C. Swick, Sonia K. Morgan-Linnell, Kimberly M. Carlson, 2011

机译：多药外排泵基因acrAB-tolCmdfA和norE在大肠杆菌临床分离株中的表达与氟喹诺酮和多药耐药性的关系
7. Expression of Multidrug Efflux Pump Genes acrAB-tolC, mdfA, and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance▿ ‡ [O] . Swick, Michelle C., Morgan-Linnell, Sonia K., Carlson, Kimberly M., 2010

机译：多药外排泵基因acrAB-tolC，mdfA和norE在大肠杆菌临床分离株中的表达与氟喹诺酮和多药耐药性的关系

Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.

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