Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers.

Chow AT; Fowler C; Williams RR; Morgan N; Kaminski S; Natarajan J

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Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers.

机译：在健康志愿者中多次静脉注射750毫克左氧氟沙星的安全性和药代动力学。

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The safety and pharmacokinetics of a once-daily high intravenous dose of levofloxacin (750 mg) in 18 healthy volunteers were studied in a double-blind, randomized, placebo-controlled, single-center parallel group study. Levofloxacin was well tolerated, and higher maximum concentration of drug in serum and area under the concentration-time curve values were achieved. For difficult-to-treat infections, high daily doses of levofloxacin may be beneficial, and intravenous administration may be preferred in certain clinical settings, such as when treating patients in intensive care units, warranting further evaluation.

机译：在一项双盲，随机，安慰剂对照，单中心平行组研究中，研究了每天一次静脉注射高剂量左氧氟沙星（750毫克）对18位健康志愿者的安全性和药代动力学。左氧氟沙星具有良好的耐受性，并且在浓度-时间曲线值下获得了更高的血清和面积中最大药物浓度。对于难以治疗的感染，每天高剂量的左氧氟沙星可能是有益的，在某些临床情况下（例如在重症监护室治疗患者时），静脉内给药可能是优选的，有待进一步评估。

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来源
《Antimicrobial agents and chemotherapy.》 |2001年第7期|共4页
作者
Chow AT; Fowler C; Williams RR; Morgan N; Kaminski S; Natarajan J;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Anti-Infective Agents; Fluoroquinolone; Ofloxacin; 抗感染药; 氟喹诺酮; 氧氟沙星;

机译：Anti-Infective Agents;Fluoroquinolone;Ofloxacin;抗感染药;氟喹诺酮;氧氟沙星;

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1. Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers. [J] . Chow AT, Fowler C, Williams RR, Antimicrobial agents and chemotherapy. . 2001,第7期

机译：在健康志愿者中多次静脉注射750毫克左氧氟沙星的安全性和药代动力学。
2. Pharmacokinetics and safety of ginsenoside Rd following a single or multiple intravenous dose in healthy Chinese volunteers. [J] . Zeng X, Deng Y, Feng Y, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2010,第3期

机译：人参皂苷Rd在健康中国志愿者中一次或多次静脉内给药后的药代动力学和安全性。
3. Phase I safety and pharmacokinetic study of magnesium isoglycyrrhizinate after single and multiple intravenous doses in chinese healthy volunteers. [J] . Sun L, Shen J, Pang X, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2007,第6期

机译：中国健康志愿者单次和多次静脉内注射异甘草酸镁后的一期安全性和药代动力学研究。
4. Investigation of the Metabolism of TZP-101 in Healthy Volunteers after Multiple Intravenous Doses by Applying Complementary LC-MS/MS on an API 4000 Qtrap and an LTQ-Orbitrap [C] . Ming Qi, Mark Gohdes, Ryan Berko, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：通过在API 4000 QTRAP施用互补LC-MS / MS和LTQ-orbitrap施用互补LC-MS / MS后，在多静脉内剂量后对健康志愿者进行TZP-101的代谢调查
5. Pharmacokinetics, tissue depletion, target animal safety and live animal swab test accuracy after administration of long-acting oxytetracycline at double the label dose in healthy calves. [D] . TerHune, Terry Norman. 1988

机译：在健康小牛中，以双倍剂量服用长效土霉素后，药代动力学，组织耗竭，目标动物安全性和活体拭子测试准确性。
6. Note: Safety and Pharmacokinetics of Multiple 750-Milligram Doses of Intravenous Levofloxacin in Healthy Volunteers [O] . Andrew T. Chow, Cynthia Fowler, R. Rex Williams, 2001

机译：注意：在健康志愿者中静脉注射左氧氟沙星的750毫克剂量的安全性和药代动力学
7. Safety and Pharmacokinetics of Multiple 750-Milligram Doses of Intravenous Levofloxacin in Healthy Volunteers [O] . Chow, Andrew T., Fowler, Cynthia, Williams, R. Rex, 2001

机译：健康志愿者中静脉注射左氧氟沙星的750毫克剂量的安全性和药代动力学

Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers.

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