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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.
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Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.

机译：不动杆菌属是不动杆菌属对碳青霉烯耐药的沉默来源。

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摘要

Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla(OXA-23)-like genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla OXA-23-like genes. A similar plasmid backbone was identified in several bla OXA-23-positive A. baumannii and A. radioresistens isolates, further strengthening the vectors of exchanges for these bla OXA-23-like genes. Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla OXA-23 gene.
机译：碳青霉烯抗性主要是由鲍曼不动杆菌中获得的碳青霉烯水解的草酸酶的表达引起的。 bla OXA-23 oxacillinase基因在世界范围内越来越多地被报道，可能代表着新出现的威胁。我们的目标是鉴定碳青霉烯酶基因的祖细胞。 50不动杆菌属的集合。通过PCR和杂交技术筛选对应于几种不动杆菌属的菌株的bla（OXA-23）样基因。五个对碳青霉烯敏感的不动杆菌不育菌株具有染色体编码的bla OXA-23样基因。在几个bla OXA-23阳性的鲍曼不动杆菌和放射抗性菌株中鉴定到了相似的质粒骨架，从而进一步增强了这些bla OXA-23样基因的交换载体。因此，被确定为住院和健康患者的皮肤上鉴定出的共生细菌种（A.radiresistensens）（与鲍曼不动杆菌共有的特性）被确定为bla OXA-23基因的来源。

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