Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

MarvigR.L.; S?ndergaardM.S.R.; Damki?rS.; H?ibyN.; JohansenH.K.; MolinS.; JelsbakL.

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Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

机译：23S rRNA突变赋予铜绿假单胞菌对阿奇霉素的抗性

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The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

机译：耐药性铜绿假单胞菌的出现是治疗囊性纤维化患者长期气道感染的重要问题。在这项研究中，我们报告了临床铜绿假单胞菌DK2分离株中阿奇霉素耐药的发生。我们证明抗性与23S rRNA的结构域V中的特定突变（大肠杆菌编号中的A2058G，A2059G和C2611T）相关，并且将A2058G和C2611T引入菌株PAO1中会导致阿奇霉素抗性。

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《Antimicrobial agents and chemotherapy.》 |2012年第8期|共3页
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MarvigR.L.; S?ndergaardM.S.R.; Damki?rS.; H?ibyN.; JohansenH.K.; MolinS.; JelsbakL.;
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正文语种 eng
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1. Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa [J] . MarvigR.L., S?ndergaardM.S.R., Damki?rS., Antimicrobial agents and chemotherapy. . 2012,第8期

机译：23S rRNA突变赋予铜绿假单胞菌对阿奇霉素的抗性
2. MUTATIONS IN DOMAIN II OF 23 S RRNA FACILITATE TRANSLATION OF A 23 S RRNA-ENCODED PENTAPEPTIDE CONFERRING ERYTHROMYCIN RESISTANCE [J] . Dam M., Tenson T., Mankin AS., Journal of Molecular Biology . 1996,第1期

机译：23 S RRNA的域II中的突变有助于赋予红霉素抗性的23 S RRNA编码的五肽的翻译。
3. Direct real-time PCR-based detection of Neisseria gonorrhoeae 23S rRNA mutations associated with azithromycin resistance [J] . Trembizki Ella, Buckley Cameron, Donovan Basil, The Journal of Antimicrobial Chemotherapy . 2015,第12期

机译：基于直接实时PCR的Neisseria淋病的检测23s与氮霉素抗性相关的RRNA突变
4. EFFECT OF QUORUM QUENCHING WITH AZITHROMYCIN ON PSEUDOMONAS AERUGINOSA ASSOCIATED OTITIS EXTERNA/MEDIA IN DOGS [C] . Modest Venqust, Javid Hosseini, Darja Kusar, Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：氮杂霉素对铜绿假单胞菌对铜绿假单胞菌的影响
5. Antibiotic resistance mechanisms in Pseudomonas aeruginosa biofilms: The contributions of RND efflux pumps in response to carbenicillin and azithromycin [D] . Gillis, Richard John 2005

机译：铜绿假单胞菌生物膜的抗生素耐药机制：RND外排泵对羧苄青霉素和阿奇霉素的贡献
6. Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa [O] . Rasmus Lykke Marvig, Mette S. R. Søndergaard, Søren Damkiær, 2012

机译：23S rRNA突变赋予铜绿假单胞菌对阿奇霉素的抗性
7. Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa [O] . Marvig, Rasmus Lykke, Søndergaard, Mette S. R., Pedersen, Søren Damkiær, 2012

机译：23s rRNa的突变赋予铜绿假单胞菌对阿奇霉素的抗性

Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

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