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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Origin and evolution of the AmpC beta-lactamases of Citrobacter freundii.
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Origin and evolution of the AmpC beta-lactamases of Citrobacter freundii.

机译：弗氏柠檬酸杆菌AmpCβ-内酰胺酶的起源和进化。

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摘要

To determine whether the widespread clinical use of beta-lactams has been selective for Citrobacter freundii-derived alleles of plasmid ampC genes, we generated a Bayesian consensus phylogeny of the published ampC sequences and compared the MICs of 16 beta-lactam antibiotics for Escherichia coli strains containing cloned copies of the C. freundii ampC alleles. We found that for the majority of compounds investigated, there has been essentially no increase in beta-lactam resistance conferred by those alleles. We also found that ampC alleles from the chromosomes of two beta-lactam-sensitive C. freundii strains isolated in the 1920s, before the clinical use of antibiotics, were as effective at providing beta-lactam resistance in E. coli as were the plasmid-borne alleles from beta-lactam-resistant clinical isolates. These results suggest that selection for increased resistance to beta-lactam antibiotics has not been a significant force directing the evolution of the C. freundii ampC alleles found in beta-lactam-resistant clinical isolates.
机译：为了确定β-内酰胺的广泛临床使用是否对弗氏柠檬酸杆菌衍生的质粒ampC基因等位基因具有选择性，我们生成了已发表ampC序列的贝叶斯共识系统发育，并比较了大肠杆菌菌株的16种β-内酰胺抗生素的MIC包含弗氏梭菌ampC等位基因的克隆副本。我们发现，对于大多数研究的化合物，这些等位基因赋予的β-内酰胺抗性基本上没有增加。我们还发现，在临床应用抗生素之前，从1920年代分离的两个β-内酰胺敏感的弗氏梭菌菌株的染色体中获得的ampC等位基因在大肠杆菌中提供β-内酰胺抗性的效果与质粒-来自耐β-内酰胺的临床分离株携带的等位基因。这些结果表明，选择增加对β-内酰胺类抗生素的耐药性并不是指导在β-内酰胺类耐药临床分离株中发现的弗氏梭菌ampC等位基因进化的重要力量。

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