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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides.
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Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides.

机译:在捷克共和国,耐甲氧西林的凝固酶阴性葡萄球菌中对大环内酯类和林可酰胺类耐药的机制普遍存在,并且对林可酰胺类耐药的机制尚不确定。

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摘要

High occurrence of the non-macrolide-lincosamide-streptogramin B resistance genes msrA (53%) and linA/linA' (30%) was found among 98 methicillin-resistant coagulase-negative staphylococci additionally resistant to macrolides and/or lincosamides. The gene msrA predominated in Staphylococcus haemolyticus (43 of 62 isolates). In Staphylococcus epidermidis, it was present in 7 of 27 isolates. A novel mechanism of resistance to lincosamides appears to be present in 10 genetically related isolates of S. haemolyticus in the absence of ermA, ermC, msrA, and linA/linA'.
机译:在98个耐甲氧西林的凝固酶阴性葡萄球菌中还发现了非大环内酯-林可酰胺-链霉菌素B耐药基因msrA(53%)和linA / linA'(30%),另外还对大环内酯类和/或林可酰胺类耐药。 msrA基因在溶血性葡萄球菌中占主导地位(62个分离株中的43个)。在表皮葡萄球菌中,它存在于27个分离物中的7个中。在不存在ermA,ermC,msrA和linA / linA'的情况下,溶血链球菌的10个遗传相关分离物中似乎存在对林可酰胺类耐药的新机制。

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