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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa.
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Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa.

机译：铜绿假单胞菌对碳青霉烯耐药的分子流行病学和机制。

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摘要

The contributions of different mechanisms of resistance to carbapenems among a collection of imipenem- and meropenem-nonsusceptible Pseudomonas aeruginosa isolates were investigated. This screening included the recently reported extended-spectrum cephalosporinases (ESACs) weakly hydrolyzing carbapenems. Eighty-seven percent of the studied isolates were resistant to imipenem. Genes encoding metallo-beta-lactamases or carbapenem-hydrolyzing oxacillinases were not identified. The main mechanism associated with imipenem resistance was the loss of outer membrane protein OprD. Identification of overexpressed ESACs and loss of OprD were observed for 65% of the isolates, all being fully resistant to imipenem. Resistance to meropenem was observed in 78% of the isolates, with all but one also being resistant to imipenem. Overexpression of the MexAB-OprM, MexXY-OprM, or MexCD-OprJ efflux systems was observed in 60% of the isolates, suggesting the contribution of efflux mechanisms in resistance to meropenem. The loss of porin OprD and the overproduction of ESACs were observed in 100% and 92% of the meropenem-resistant isolates, respectively. P. aeruginosa can very often accumulate different resistance mechanisms, including ESAC production, leading to carbapenem resistance.
机译：研究了对亚胺培南和美罗培南不敏感的铜绿假单胞菌分离株中对碳青霉烯类耐药的不同机制的贡献。该筛选包括最近报道的弱水解碳青霉烯类的广谱头孢菌素酶（ESAC）。研究的分离株中有百分之八十七对亚胺培南具有抗性。编码金属β-内酰胺酶或碳青霉烯水解草酸酶的基因尚未鉴定。与亚胺培南耐药相关的主要机制是外膜蛋白OprD的丢失。对于65％的分离株，均鉴定出过表达的ESAC和OprD缺失，所有分离株均对亚胺培南具有完全抗性。在78％的分离物中观察到了对美罗培南的抗药性，除一株外，其他所有药对亚胺培南也有抗药性。在60％的分离物中观察到MexAB-OprM，MexXY-OprM或MexCD-OprJ外排系统的过表达，表明外排机制对美洛培南具有抗性。分别在100％和92％的耐美罗培南的分离株中观察到孔蛋白OprD的丢失和ESAC的过量生产。铜绿假单胞菌通常会积累不同的抗药性机制，包括ESAC产生，从而导致碳青霉烯抗药性。

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