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首页> 外文期刊>Antimicrobial agents and chemotherapy. >The antibiotic gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases.
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The antibiotic gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases.

机译：抗生素庆大霉素可抑制GTPases Arf1 / 2家族的特定蛋白运输功能。

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摘要

Gentamicin is a highly efficacious antibiotic against Gram-negative bacteria. However, its usefulness in treating infections is compromised by its poorly understood renal toxicity. Toxic effects are also seen in a variety of other organisms. While the yeast Saccharomyces cerevisiae is relatively insensitive to gentamicin, mutations in any one of approximately 20 genes cause a dramatic decrease in resistance. Many of these genes encode proteins important for translation termination or specific protein-trafficking complexes. Subsequent inspection of the physical and genetic interactions of the remaining gentamicin-sensitive mutants revealed a network centered on chitin synthase and the Arf GTPases. Further analysis has demonstrated that some conditional arf1 and gea1 alleles make cells hypersensitive to gentamicin under permissive conditions. These results suggest that one consequence of gentamicin exposure is disruption of Arf-dependent protein trafficking.
机译：庆大霉素是针对革兰氏阴性菌的高效抗生素。但是，由于对肾脏毒性的了解不足，因此无法有效地治疗感染。在其他多种生物中也可见到毒性作用。尽管酵母酿酒酵母对庆大霉素相对不敏感，但大约20个基因中任何一个的突变都会导致耐药性急剧下降。这些基因中的许多编码对翻译终止或特定的蛋白质贩运复合体重要的蛋白质。随后对剩余的庆大霉素敏感突变体的物理和遗传相互作用的检查揭示了一个以几丁质合酶和Arf GTP酶为中心的网络。进一步的分析表明，某些条件性的arf1和gea1等位基因使细胞在允许的条件下对庆大霉素高度敏感。这些结果表明庆大霉素暴露的结果之一是破坏了Arf依赖性蛋白的运输。

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