Nitrilase-catalyzed selective hydrolysis of dinitriles and green access to the cyanocarboxylic acids of pharmaceutical importance

Zhu D; Mukherjee C; Biehl ER; Hua L

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Nitrilase-catalyzed selective hydrolysis of dinitriles and green access to the cyanocarboxylic acids of pharmaceutical importance

机译：腈水解酶催化的二腈选择性水解和绿色获得具有重要意义的氰基羧酸

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To further explore its synthetic applications, the nitrilase bll6402 from Bradyrhizobium japonicum strain USDA110 has been examined toward the hydrolysis of various dinitriles. It has been found that nitrilase bll6402 effectively hydrolyzed alpha,omega-dinitriles to omega-cyanocarboxylic acids, and the selectivity was independent of the substrate chain length. This feature is distinct from all the known nitrilases of various sources. Nitrilase bll6402 was thus applied to the synthesis of 1-cyanocycloalkaneacetic acids, the useful precursors for the synthesis of gabapentin and its analogues.

机译：为了进一步探索其合成应用，已经研究了日本根瘤菌（Bradyrhizobium japonicum）菌株USDA110的腈水解酶bll6402对各种二腈的水解作用。已经发现腈水解酶bll6402有效地将α，ω-二腈水解为ω-氰基羧酸，并且选择性与底物链长无关。该特征不同于各种来源的所有已知的腈水解酶。因此将腈水解酶bll6402应用于1-氰基环烷乙酸的合成，这是合成加巴喷丁及其类似物的有用前体。

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《Advanced synthesis & catalysis》 |2007年第10期|共4页
作者
Zhu D; Mukherjee C; Biehl ER; Hua L;
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正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
关键词
cyanocarboxylic acids; dinitriles; enzyme catalysis; hydrolysis; nitrilase; ARABIDOPSIS-THALIANA; BIOCATALYTIC HYDROLYSIS; SYNTHETIC APPLICATIONS; ORGANIC-SYNTHESIS; ENZYME; BIOTRANSFORMATIONS; ENANTIOSELECTIVITY; ATNIT1;

机译：氰基羧酸;二腈;酶催化;水解;硝化酶;ARABIDOPSIS-THALIANA;生物催化水解;合成应用;有机合成;酶;生物转化;对映选择性;ATNIT1;

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1. Nitrilase-catalyzed selective hydrolysis of dinitriles and green access to the cyanocarboxylic acids of pharmaceutical importance [J] . Zhu D, Mukherjee C, Biehl ER, Advanced synthesis & catalysis . 2007,第10期

机译：腈水解酶催化的二腈选择性水解和绿色获得具有重要意义的氰基羧酸
2. Selective Hydrolysis of Aliphatic Dinitriles to Monocarboxylic Acids by a Nitrilase from Arabidopsis thaliana [J] . Franz Effenberger, Steffen Obwald Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2001,第12期

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机译：通过酰胺植物的孢子表面产生酸胃酸的三烷基酸的生产枯草芽孢杆菌的孢子表面

Nitrilase-catalyzed selective hydrolysis of dinitriles and green access to the cyanocarboxylic acids of pharmaceutical importance

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