Innate Immune Receptors and IRF Family Transcription Factors

TakashI Fujita; Mitsutoshi Yoneyama

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Innate Immune Receptors and IRF Family Transcription Factors

机译：先天免疫受体和IRF的家人转录因子

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Toll like receptors (TLRs) function as signaling receptors for pathogen-derived molecules and provoke innate immune responses, which are preparatory for initiating acquired immunity. Each TLR triggers both common and unique signals, resulting in the activation of a specific set of transcription factors and hence the activation of common and specific target genes, Some members of the Interferon Regulatory Factor (IRF) family of transcription factors are specifically activated by TLR signaling and participate in the critical processes of innate immunity. Recently, a non-TLR receptor that recognizes viral double stranded RNA and participates in the antiviral innate responses was identified.

机译：通常Toll样受体信号功能pathogen-derived分子和受体引起先天免疫反应,准备启动后天免疫。每个TLR触发共同和独特的信号,导致一组特定的激活转录因子,从而激活的常见的和特定的目标基因,一些成员干扰素调节因子(IRF)的家庭转录因子是专门激活TLR信号和参与的关键先天免疫的过程。受体识别病毒双链RNA和参与抗病毒先天被确认的反应。

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《Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents》 |2005年第1期|29-33|共5页
作者
TakashI Fujita; Mitsutoshi Yoneyama;
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作者单位

Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome,Bunkyo, Tokyo 113-8613, Japan;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Interferon Regulatory Factors; Transcription Factors; Toll-Like Receptor Signaling Pathwaydouble stranded RNAToll-Like Receptorsfamilyampligen;

机译：干扰素调节因子,转录因素;toll样受体信号Pathwaydouble滞留RNAToll-LikeReceptorsfamilyampligen;

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Innate Immune Receptors and IRF Family Transcription Factors

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