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首页> 外文期刊>Journal of cellular physiology. >Ciliary dynein arms: Cytoplasmic preassembly, intraflagellar transport, and axonemal docking
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Ciliary dynein arms: Cytoplasmic preassembly, intraflagellar transport, and axonemal docking

机译：纤毛动力蛋白臂:细胞质预装配,intraflagellar运输,axonemal对接

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Abstract The microtubular scaffold of motile cilia—the axoneme, is decorated with dynein arms, which are large multiprotein complexes essential for ciliary motility. Dynein arms are arranged along the length of the axoneme in a precise?repeating pattern, converting chemical energy from ATP hydrolysis into ciliary mechanical movement. How these complicated molecular machines are assembled coordinately and accurately, starting from mere polypeptide chains in the cytoplasm, remains a fascinating yet perplexing question. Rapidly emerging evidence, from multiple studies carried out with different model organisms and with various methodologies, has highlighted the existence of a dedicated assembly pathway. Here, we summarize recent progress made in clarifying the axonemal dynein arm assembly process, focusing on individual assembly steps, including cytoplasmic preassembly, intraflagellar transport, and axonemal docking.
机译：抽象的运动型的微管支架cilia-the基因丝,是装饰着动力蛋白臂,这是大multiprotein复合物重要吗纤毛蠕动。沿长度的基因丝准确吗?能量从ATP水解成纤毛机械运动。分子机器的装配协调和准确的说,从单纯的多肽链在细胞质中,仍然是一个令人着迷的令人困惑的问题。从多个研究不同生物模型和各种方法,凸显了一个专用的存在吗装配路径。进展在澄清axonemal动力蛋白手臂装配过程,关注个体装配步骤,包括细胞质预装配、intraflagellar运输和axonemal对接。

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