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首页> 外文期刊>Journal of cellular physiology. >MicroRNAs: Small molecules with a large impact on pre-eclampsia
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MicroRNAs: Small molecules with a large impact on pre-eclampsia

机译：小分子核糖核酸:小分子有很大的影响

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摘要

As critical mediators in biological processes, microRNAs (miRNAs) which are small and endogenous noncoding RNAs have been associated with disease progression, cell proliferation, and development. Pre-eclampsia (PE), a pregnancy-related disorder with no early markers or symptoms is recognized as the main reason for fetal and maternal mortality and morbidity in the initial steps or even during pregnancy, worldwide. Clinical symptoms usually appear in the third trimester of the pregnancy. Although numerous research have unraveled several aspects of placenta development abnormalities associated with abnormal trophoblastic invasion and angiogen-esis modification, many questions about the PE pathogenesis remains unanswered. A large number of studies have shown the important role of miRNAs as potential biomarkers in the PE prognosis and diagnosis. Here, the latest investigations about the PE and placental miRNAs expression, as well as, the crucial role of miRNA molecules including miR-210 and miR-155 which are deregulated in patients with PE, will be argued.
机译：作为生物过程至关重要的介质,小型和内源性小分子核糖核酸(microrna)非编码rna一直与疾病有关进展,细胞增殖和发展。先兆子痫(PE),与怀孕相关的疾病没有标记或早期症状是公认的胎儿和产妇的主要原因或死亡率和发病率在最初的步骤即使在怀孕期间,全世界。症状通常出现在三个月大的孩子怀孕。瓦解胎盘发展的几个方面异常与异常有关滋养层的入侵和angiogen-esis修改,许多关于体育的问题发病机制有待解答。研究显示的重要作用PE microrna的潜在生物标志物预后和诊断。调查关于体育和胎盘microrna表达式,以及,microrna的至关重要的作用分子包括mir - 210和mir - 155管制PE患者,会认为。

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