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首页> 外文期刊>Journal of cellular physiology. >An update on potentials and promises of T cell co-signaling molecules in transplantation
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An update on potentials and promises of T cell co-signaling molecules in transplantation

机译：更新潜力和T细胞的承诺co-signaling分子移植

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摘要

The promising outcomes of immune-checkpoint based immunotherapies in cancer have provided a proportional perspective ahead of exploiting similar approaches in allotransplantation. Belatacept (CTLA-4-lg) is an example of costimulation blockers successfully exploited in renal transplantation. Due to the wide range of regulatory molecules characterized in the past decades, some of these molecules might be candidates as immunomodulators in the case of tolerance induction in transplantation. Although there are numerous attempts on the apprehension of the effects of co-signaling molecules on immune response, the necessity for a better understanding is evident. By increasing the knowledge on the biology of co-signaling pathways, some pitfalls are recognized and improved approaches are proposed. The blockage of CD80/CD28 axis is an instance of evolution toward more efficacy. It is now evident that anti-CD28 antibodies are more effective than CD80 blockers in animal models of transplantation. Other co-signaling axes such as PD-1/PD-L1, CD40/CD154, 2B4/CD48, and others discussed in the present review are examples of critical immunomodulatory molecules in allogeneic transplantation. We review here the outcomes of recent experiences with co-signaling molecules in preclinical studies of solid organ transplantation.
机译：基于immune-checkpoint的承诺的结果免疫疗法在癌症提供了一个比例的角度利用类似的方法在异体移植术。Belatacept (CTLA-4-lg)就是一个例子聚集有关阻滞剂成功利用肾移植。过去监管分子特征几十年,这些分子可能候选人的情况下免疫调制剂耐受诱导移植。有许多尝试理解co-signaling分子的影响免疫反应,更好的必要性理解是显而易见的。co-signaling生物学的知识途径,识别和一些陷阱提出了改进的方法。CD80 / CD28轴向进化的一个实例更多的功效。抗体是更有效的比CD80阻滞剂移植的动物模型。co-signaling轴等PD-1 / PD-L1 CD40 / CD154的,2 b4 / CD48因子,和其他人讨论了在当下复习是重要的免疫调节的例子分子在同种异体移植。回顾最近的经历的结果在临床前与co-signaling分子实体器官移植的研究。

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