• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Gut microbiome and cancer immunotherapy
【24h】

Gut microbiome and cancer immunotherapy

机译：肠道微生物和癌症免疫疗法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Gut microbiome has received significant attention for its influences on a variety of host functions, especially immune modulation. With the next-generation sequencing methodologies, more knowledge is gathered about gut microbiome and its irreplaceable role in keeping the balance between human health and diseases is figured out. Immune checkpoint inhibitors (ICIs) are one of the most innovational cancer immunotherapies across cancer types and significantly expand the therapeutic options of cancer patients. However, a proportion of patients show no effective responses or develop immune-related adverse events when responses do occur. More important, it is demonstrated that the therapeutic response or treatment-limiting toxicity of cancer immunotherapy can be ameliorated or diminished by gut microbiome modulation. In this review, we first introduce the relationship between gut microbiome and cancer immunotherapy. And then, we expound the impact of gut microbiome on efficacy and toxicity of cancer immunotherapy. Further, we review approaches to manipulating gut microbiome to regulate response to ICIs. Finally, we discuss the current challenges and propose future directions to improve cancer immunotherapy via gut microbiome manipulation.
机译：肠道微生物组已经收到了广泛的关注不同的主机上的影响功能,特别是免疫调制。新一代测序方法,更多知识是对肠道微生物和聚集保持平衡的不可替代的作用人类健康和疾病之间的发现。免疫抑制剂检查站(艾多酷)之一最创新的癌症免疫疗法在癌症和显著扩大癌症患者的治疗选择。比例的患者没有有效或开发的几种不良的反应事件反应确实发生了。这是证明治疗的反应或treatment-limiting毒性的癌症免疫疗法可以改善或消失肠道微生物组调制。首先介绍了肠道之间的关系微生物和癌症免疫疗法。阐述了肠道微生物对疗效的影响癌症免疫疗法和毒性。复习方法操纵肠道微生物组监管应对艾多酷。当前的挑战并提出未来提高癌症免疫疗法通过方向肠道微生物组操作。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号