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首页> 外文期刊>Genetic testing and molecular biomarkers >MTHFR C677T and Factor V Leiden in Recurrent Pregnancy Loss: A Study Among an Endogamous Group in North India
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MTHFR C677T and Factor V Leiden in Recurrent Pregnancy Loss: A Study Among an Endogamous Group in North India

机译：MTHFR C677T和V莱顿在复发性因素怀孕损失:一群研究中一个同族结婚的在北印度

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Aim: In our study an attempt has been made to find the prevalence of genetic thrombophilia in recurrent pregnancy loss (RPL). Methods: Methylene tetrahydrofolate reductase C677 (MTHFR C677T) and factor V Leiden ( FVL) were investigated in 84 Rajput women with two or more pregnancy losses and in 80 age- and ethnicitymatched healthy controls. Restriction digestions of polymerase chain reaction product with Hinfl and Mnl I were used for MTHFR C677T and FVL polymorphism detection, respectively. Results: MTHFR C677T mutation was found in 9/84 patients (10.71%) and 2/80 controls (2.5%), yielding an odds ratio (OR) for RPL related to MTHFR C677T of 4.68 (95% confidence interval = 0.98-22.37; p = 0.03). FVL was found in 4/84 patients (4.76%) and none among the controls, yielding a modified OR for RPL related to FVL of 9.00 (95% CI = 0.48-169.9; p = 0.05). Both, MTHFR C677T and FVL were not found to be significantly more prevalent in patients than controls as a whole. However, MTHFR C677T showed significant association with early pregnancy loss (OR = 6.3; 95% CI = 1.22-32.85; p-value = 0.03; Bonferroni-corrected p-value = 0.04). Conclusions: Our study supports the association between MTHFR C677T and patients with early RPL among north Indian Rajputs and strengthens the notion that thrombophilia plays a role in this clinical entity.
机译：目的:在我们的研究尝试基因的流行血栓形成倾向复发性流产(RPL)。亚甲基tetrahydrofolate还原酶C677 (MTHFRC677T莱顿(FVL) V)和因素调查84年拉其普特人两个或两个以上的女性怀孕80年年龄和损失ethnicitymatched健康对照组。聚合酶链反应产品的一点与Hinfl Mnl我是用于MTHFR C677T分别和FVL多态性检测。结果:MTHFR C677T基因突变被发现在9/84病人(10.71%)和控制(2.5%),2/80产生一个比值比(或)RPL有关MTHFR C677T 4.68(95%置信区间=0.98 - -22.37;患者(4.76%)和没有控制,产生的修改或RPL FVL相关9.00 (95% CI = 0.48 - -169.9;C677T和FVL并不显著更普遍的病人比控制整体。与怀孕早期损失(OR = 6.3;95%可信区间= 1.22 - -32.85;Bonferroni-corrected假定值= 0.04)。结论:我们的研究支持协会早期RPL之间MTHFR C677T和患者在印度北部的城堡和加强认为血栓形成倾向起着作用临床实体。

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