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首页> 外文期刊>Genetic testing and molecular biomarkers >Glutathione S-Transferase M1 and T1 Genes and Susceptibility to Chronic Myeloid Leukemia:A Meta-Analysis
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Glutathione S-Transferase M1 and T1 Genes and Susceptibility to Chronic Myeloid Leukemia:A Meta-Analysis

机译：谷胱甘肽S-Transferase M1和T1和基因慢性骨髓性白血病易感性:A荟萃分析

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Variants of glutathione S-transferase Ml (GSTM1) and Tl (GSTT1) genes have been implicated as risk factors for chronic myeloid leukemia (CML). However, the genetic association studies that examined the relation between the null genotypes of GSTM1 and GSTT1 genes and risk of developing CML gave conflicting or inconclusive results. In an attempt to interpret these results, a meta-analysis of all available studies (nine studies, with 757 cases and 1959 controls) was performed. In the meta-analysis the pooled odds ratios (OR) were estimated using random effects models. The heterogeneity between studies, the sources of potential bias, and the consistency of genetic effects across ethnicities were explored. Cumulative meta-analysis was also performed. Overall, the meta-analysis showed nonsignificant association between GSTM1 null genotype and CML (OR = 1.00 [0.83- 1.20]) and lack of heterogeneity between the studies (p_Q = 0.87). The association was also nonsignificant in Whites, East Asians, and Indians: OR = 1.38 (0.43-4.46), 0.94 (0.65-1.35), and 1.16 (0.74-1.82), respectively. However, GSTT1 null genotype was associated with increased risk of CML (OR =1.57 [1.13-2.17]) and the heterogeneity between studies was significant (p_Q = 0.04). In Indians, the association was significant (OR = 2.89 [1.56-5.35]) whereas in East Asians it was not significant (OR = 1.07 [0.74-1.54]). The combined GSTM1 normal/ GSTT1 null genotypes produced significant association (OR = 1.95 [1.17-3.24]). Cumulative meta-analysis for GSTT1 gene showed an upward trend in risk effect, whereas the trend was downward in GSTM1. There was a differential magnitude of effect in large versus small studies. In conclusion, the accumulated evidence indicated an association between GSTT1 null genotype and CML.
机译：变异的谷胱甘肽S-transferase毫升(GSTM1基因)和Tl (GSTT1)基因已经被牵连的风险因素对慢性粒细胞白血病(CML)。然而,基因关联研究研究了零基因型之间的关系GSTM1和GSTT1基因和发展的风险CML给冲突或不确定的结果。试图解释这些结果所有可用的荟萃分析研究(9研究中,757例病例和1959例对照)执行。比率(或)使用随机效应估计模型。潜在的偏见的来源的一致性跨种族遗传效应进行了探讨。累积荟萃分析也执行。总的来说,荟萃分析显示无意义的零基因型和CML GSTM1基因之间的联系(或= 1.00[0.83 - 1.20])和缺乏之间的异质性研究(p_Q = 0.87)。协会也是无意义的东亚人,白人和印第安人:或者= 1.38(0.43 - -4.46), 0.94(0.65 - -1.35),和1.16分别为(0.74 - -1.82)。基因型与风险增加有关CML(或= 1.57[1.13 - -2.17])和异质性之间的研究是重要的(p_Q = 0.04)。印度人,协会是重要的(或=2.89(1.56 - -5.35))而在东亚人不显著(或= 1.07[0.74 - -1.54])。结合GSTM1基因正常/ GSTT1无效基因型产生显著关联(或= 1.95[1.17 - -3.24])。风险影响的基因表现出上升趋势,而GSTM1基因的趋势是向下的。是一个微分级的影响大吗对小型研究。积累的证据表明一个协会GSTT1无效基因型和CML之间。

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