Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).

Coro J; Little S; Yardley V; Suarez M; Rodriguez H; Martin N; Perez-Pineiro R

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Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).

机译：新的N4-（苄基）亚氨基连接的双（1,3,5-噻二嗪烷-2-硫酮）的合成和抗原生动物评价。

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The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.

机译：N（4）-（苄基）的新型N（4）-（苄基）亚磺酰基连接的双（1,3,5-噻二嗪烷-2-硫酮）（双-THTT）衍生物的合成和体外抗原生动物评价公开了亚精胺。几种新的双-THTT具有对抗杜氏乳酸杆菌和克鲁氏梭菌的体外活性，这些活性与目前使用的原杀虫剂相当或更好。

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来源
《Archiv der Pharmazie》 |2008年第11期|共6页
作者
Coro J; Little S; Yardley V; Suarez M; Rodriguez H; Martin N; Perez-Pineiro R;
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正文语种 eng
中图分类药学;
关键词
Animals; Antiprotozoal Agents; Drug Evaluation; Preclinical; Leishmania donovani; 动物; 抗原虫药; 利什曼原虫; 杜氏; 精脒; 构效关系; 硫酮类; 锥虫; 克氏;

机译：Animals;Antiprotozoal Agents;Drug Evaluation;Preclinical;Leishmania donovani;动物;抗原虫药;利什曼原虫;杜氏;精脒;构效关系;硫酮类;锥虫;克氏;

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1. Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones). [J] . Coro J, Little S, Yardley V, Archiv der Pharmazie . 2008,第11期

机译：新的N4-（苄基）亚氨基连接的双（1,3,5-噻二嗪烷-2-硫酮）的合成和抗原生动物评价。
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Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).

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