2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.

Gonzalez-Rosende ME; Olivar T; Castillo E; Sepulveda-Arques J

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2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.

机译：2-磺酰亚胺二氢嘧啶类：一类新的止痛化合物。

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A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.

机译：已经合成了一系列2-磺酰氨基二氢嘧啶衍生物，并在体内对其抗伤害性和抗炎活性进行了评估。将结果与乙酰水杨酸进行比较。化合物6Ab-d和6Be在乙酸诱导的腹部收缩试验中显示出有趣的镇痛作用。根据角叉菜胶后爪水肿试验的结果，化合物6Af显示出潜在的抗炎活性。

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《Archiv der Pharmazie》 |2008年第11期|共6页
作者
Gonzalez-Rosende ME; Olivar T; Castillo E; Sepulveda-Arques J;
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正文语种 eng
中图分类药学;
关键词
Analgesics; Animals; Anti-Inflammatory Agents; Drug Evaluation; Preclinical; 镇痛药; 动物; 消炎药; 水肿; 小鼠; 分子结构; 疼痛; 嘧啶类; 大鼠; 构效关系;

机译：Analgesics;Animals;Anti-Inflammatory Agents;Drug Evaluation;Preclinical;镇痛药;动物;消炎药;水肿;小鼠;分子结构;疼痛;嘧啶类;大鼠;构效关系;

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1. 2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds. [J] . Gonzalez-Rosende ME, Olivar T, Castillo E, Archiv der Pharmazie . 2008,第11期

机译：2-磺酰亚胺二氢嘧啶类：一类新的止痛化合物。
2. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues [J] . Yoshiyasu Higashikawa, Shinichi Suzuki Forensic Toxicology . 2008,第1期

机译：1-（2-苯乙基）-4-（N-丙炔基丙氨酸）哌啶（芬太尼）及其相关化合物的研究。 VI。芬太尼，甲基取代的芬太尼和其他类似物的结构-镇痛活性关系
3. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues [J] . Yoshiyasu Higashikawa, Shinichi Suzuki Forensic toxicology . 2008,第1期

机译：1-（2-苯乙基）-4-（N-丙炔基丙氨酸）哌啶（芬太尼）及其相关化合物的研究。 VI。芬太尼，甲基取代的芬太尼和其他类似物的结构-镇痛活性关系
4. TRITIUM LABELING OF A CLASS OF SPIROOXINDOLAMINES POSSESSING ANALGESIC PROPERTIES [C] . Peter Strom, Jonas Malmquist, Jonas Hansson, International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds . 2004

机译：氚标记一类螺氧吲哚胺具有镇痛性的特性
5. SYNTHESIS OF NEW POTENTIAL ANALGESIC COMPOUNDS. [D] . KIM, CHONG-HO. 1983

机译：新的潜在止痛化合物的合成。
6. Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds. [O] . M Galleni, N Franceschini, B Quinting, 1994

机译：辅助分枝杆菌D316的A类染色体β-内酰胺酶用于研究潜在的不良底物和抑制性β-内酰胺化合物的用途。
7. Studies on the Synthesis of Analgesics. LIV. Syntheses of 3-(Substituted phenyl)-4-oxazolidinone and 3-(Substituted phenyl)-3, 4, 5, 6-tetrahydro-2H-1, 3-oxazin-4-one Derivatives as Analgesics (Studies on the Syntheses of Heterocyclic Compounds. CMXXVIII) [O] . TETSUJI KAMETANI, KAZUO KIGASAWA, MINEHARU HIIRAGI, 1981

机译：镇痛药合成研究。 LIV。合成的3-（取代的苯基）-4-恶唑烷酮和3-（取代的苯基）-3,4,5,6-四羟基-2H-1,3-恶化-4-一种衍生物作为镇痛药（关于合成的研究杂环化合物。CMXXVIII）
8. Frequent Sub-Structure-Based Approaches for Classifying Chemical Compounds. [R] . Deshpande, M., Kuramochi, M., Karypis, G. 2003

机译：基于子结构的频繁化学化合物分类方法。

2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.

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