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首页> 外文期刊>Aquatic Toxicology >Impact of PCB mixture (Aroclor 1254) and TBT and a mixture of both on swimming behavior, body growth and enzymatic biotransformation activities (GST) of young carp (Cyprinus carpio)
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Impact of PCB mixture (Aroclor 1254) and TBT and a mixture of both on swimming behavior, body growth and enzymatic biotransformation activities (GST) of young carp (Cyprinus carpio)

机译：多氯联苯混合物（Aroclor 1254）和TBT以及两者的混合物对幼鲤（鲤）的游泳行为，身体生长和酶促生物转化活性（GST）的影响

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摘要

The sensitivity of carp to chronical stress due to single and combined mixtures (each 50%) of TBT and PCB was evaluated under laboratory conditions. And concluded, mixed exposures were partially more or less toxic than single ones. Xenobiotic stress led to both decreased mean daily swimming speed and an increased mean swimming speed during darkness. Also a decreased preferred swimming depth (nearer to the surface) during nighttime was observed. We found approximately synergistic effects of TBT and PCB in swimming behavior of carp exposed to those mixtures. PCB did not affect the body growth significantly, TBT-stress led to a decreased body growth and the exposure to PCB-TBT mixture caused an approximately additive decrease of body growth. Measurement of biotransformation potential measured as GST enzyme activity showed both increasing or decreasing activity levels after exposure to single and mixture chemical combinations (approximately additive, antagonistic and synergistic). Nevertheless, we had to conclude that all methods tested were useful to screen subacute effects of single as well as mixed xenobiotic chemicals on carp, which is the prerequisite for an investigation of samples taken from the environment.
机译：在实验室条件下评估了鲤鱼对TBT和PCB的单一混合物和混合混合物（各占50％）引起的慢性应激的敏感性。并得出结论，混合暴露比单次暴露具有部分毒性。异种生物胁迫导致平均每日游泳速度下降和黑暗期间平均游泳速度增加。还观察到夜间的优选游泳深度（靠近表面）减小。我们发现TBT和PCB在暴露于这些混合物的鲤鱼的游泳行为中具有大约协同作用。 PCB并未显着影响人体生长，TBT压力导致人体生长下降，而暴露于PCB-TBT混合物则导致人体生长约加和下降。以GST酶活性衡量的生物转化潜力的测量显示，在暴露于单一和混合化学组合（近似加性，拮抗性和协同作用）后，活性水平升高或降低。然而，我们必须得出结论，所有测试的方法均有助于筛选单一或混合异种生物化学物质对鲤鱼的亚急性影响，这是研究从环境中取样的先决条件。

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