Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo(3.3.0)octan-4-one moiety, Part II.

Oh CH; Lee SC; Park SJ; Lee IK; Nam KH; Lee KS; Chung BY; Cho JH

首页> 外文期刊>Archiv der Pharmazie >Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo(3.3.0)octan-4-one moiety, Part II.

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Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo(3.3.0)octan-4-one moiety, Part II.

机译：具有1，3-二氮杂双环（3.3.0）octan-4-one部分的1个β-甲基卡巴南的合成及抗菌活性，第二部分。

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The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria are tested and the effect of substituent on the bicyclic ring was investigated. A particular compound (11 h) having aminoethyl group showed the most potent antibacterial activity.

机译：描述了具有1，3-二氮杂双环[3.3.0] octan-4-one部分的一系列新的1β-甲基碳烯化合物的合成。测试了它们对革兰氏阳性和革兰氏阴性细菌的体外抗菌活性，并研究了取代基对双环的影响。具有氨基乙基的特定化合物（11小时）显示出最有效的抗菌活性。

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《Archiv der Pharmazie》 |1999年第4期|共4页
作者
Oh CH; Lee SC; Park SJ; Lee IK; Nam KH; Lee KS; Chung BY; Cho JH;
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正文语种 eng
中图分类药学;
关键词
Bacteria; Carbapenems; 细菌; 卡巴配能类;

机译：Bacteria;Carbapenems;细菌;卡巴配能类;

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1. Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo(3.3.0)octan-4-one moiety, Part II. [J] . Oh CH, Lee SC, Park SJ, Archiv der Pharmazie . 1999,第4期

机译：具有1，3-二氮杂双环（3.3.0）octan-4-one部分的1个β-甲基卡巴南的合成及抗菌活性，第二部分。
2. Synthesis and Antibacterial Activity of 1beta-Methylcarbapenems Having a 2, 2-disubstituted-1, 3-Diazabicyclo(3.3.0)octan-4-one Moiety and Related Compounds. Part III. [J] . Oh CH, Dong HG, Cho HW, Archiv der Pharmazie . 2002,第5期

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8. Bimanes (1,5-Diazabicyclo(3.3.0)Octadiendiones). Laser Activity in syn-Bimanes. [R] . Stevens, E. D., Boyer, J. H., Lau, C. M., 1990

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Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo(3.3.0)octan-4-one moiety, Part II.

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