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Hydrodynamic models for the diffusivity of type A botulinum neurotoxin

机译:水动力模型类型的扩散系数肉毒神经毒素

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The times-to-maximum effect of type A botulinum neurotoxin (BoNT-A) depend to some extent on biophysical and biochemical variables. These times range from <3 h (isolated nerve-muscle preparations) to 1-3 weeks (healthy human volunteers). Hydrodynamic equations were solved for different models, some of which produced values of the diffusion coefficient (D) that are comparable to those of other proteins. Other results differed by up to five orders of magnitude. Because the in vivo findings were not related to an unusually small value for D, we propose that there is a protective reservoir for BoNT-A in vivo and possibly for other serotypes.
机译:A型肉毒杆菌的times-to-maximum效应神经毒素(BoNT-A)在某种程度上依赖生物物理和生物化学变量。*从< 3 h(孤立的肌肉紧张准备工作)1 - 3周(健康的人类志愿者)。对于不同的模型,其中一些的扩散系数值(D)与其他蛋白质。结果不同的五个订单大小。相关异常小值D,我们建议有保护储层BoNT-A体内,可能其他血清型。

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