Synthesis and cytotoxicity of bis-1,3,4-oxadiazoles and bis-pyrazoles derived from 1,4-bis(5-thio-4-substituted-1,2,4-triazol-3-yl)-butane and their DNA binding studies.

Purohit M; Prasad VV; Mayur CY

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Synthesis and cytotoxicity of bis-1,3,4-oxadiazoles and bis-pyrazoles derived from 1,4-bis(5-thio-4-substituted-1,2,4-triazol-3-yl)-butane and their DNA binding studies.

机译：1,4-双（5-硫-4-取代-1,2,4-三唑-3-基）丁烷衍生的双-1,3,4-恶二唑和双吡唑及其DNA的合成和细胞毒性绑定研究。

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A new series of 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-substituted-1,2,4-triaz ol-3-yl]-butane 7-12 and 1,4-bis[5-(1-oxo-1-(3,5 dimethyl pyrazol-1-yl)-methyl)-thio-4-substitued-1,2,4-triazol-3-yl]-butane 13-18 were prepared from 1,4-bis(5[hydrazinocarbonylmethylthio]-4-substituted-1,2,4-triazol-3-yl) butane based derivativess were synthesized 1-6. All the synthesized compounds were characterized by IR, NMR and Mass spectral studies. The synthesized compounds 7-18 were screened for in-vitro cytotoxicity potential using the standard MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against a panel of three human cancer cell lines: Lung carcinoma A-549, colon carcinoma HT-29 and breast cancer MDA MB-231. DNA binding studies were conducted for three potent molecules by absorption titration method.

机译：1,4-双[5-（5-巯基-1,3,4-恶二唑-2-基-甲基）-硫代-4-取代的1,2,4-三唑--3-基的新系列]-丁烷7-12和1,4-双[5-（1-氧-1-（3,5二甲基吡唑-1-基）-甲基）-硫代-4-取代-1,2,4-三唑由1，4-双（5 [肼基羰基甲硫基] -4-取代的1,2,4-三唑-3-基）丁烷基衍生物合成1-6，制备了-3--3-基]-丁烷13-18。所有合成的化合物都通过IR，NMR和质谱研究进行了表征。使用标准的MTT（3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴化物）测定法针对一组三种人类癌细胞系筛选合成的化合物7-18的体外细胞毒性：肺癌A-549，结肠癌HT-29和乳腺癌MDA MB-231。通过吸收滴定法对三种有效分子进行了DNA结合研究。

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《Archiv der Pharmazie》 |2011年第4期|共7页
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Purohit M; Prasad VV; Mayur CY;
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1. Synthesis and cytotoxicity of bis-1,3,4-oxadiazoles and bis-pyrazoles derived from 1,4-bis(5-thio-4-substituted-1,2,4-triazol-3-yl)-butane and their DNA binding studies. [J] . Purohit M, Prasad VV, Mayur CY Archiv der Pharmazie . 2011,第4期

机译：1,4-双（5-硫-4-取代-1,2,4-三唑-3-基）丁烷衍生的双-1,3,4-恶二唑和双吡唑及其DNA的合成和细胞毒性绑定研究。
2. In-Vitro Cytotoxicity and Cell Cycle Analysis of Two Novel bis-1,2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol-3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl)-1,2,4-triazol-3-yl]-butane (MNP-16) [J] . Madhusudan N. Purohita Kuppusamy Panjamurthyb Santhini Elangob Karteek Hebbarc Yergeri C. Mayurd Sathees C. Raghavanb Nucleosides, Nucleotides and Nucleic Acids . 2011,第11期

机译：两种新型双-1,2,4-三唑衍生物：1,4-双[5-（5-巯基-1,3,4-恶二唑-2-基-甲基）-的体外细胞毒性和细胞周期分析巯基-4-（对甲苯基）-1,2,4-三唑-3-基]-丁烷（MNP-14）和1,4-双[5-（羰乙氧基甲基）-硫代-4-（p -乙氧基苯基）-1,2,4-三唑-3-基]-丁烷（MNP-16）
3. In-vitro cytotoxicity and cell cycle analysis of two novel bis-1,2, 4-triazole derivatives: 1,4-bis(5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol -3-yl)-butane (MNP-14) and 1,4-bis(5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl)-1,2,4-triazol-3-yl)-butane (MNP-16). [J] . Purohit MN, Panjamurthy K, Elango S, Nucleosides, nucleotides and nucleic acids . 2011,第10a12期

机译：两种新的双1,2,4-三唑衍生物的体外细胞毒性和细胞周期分析：1,4-双（5-（5-巯基-1,3,4-恶二唑-2-基-甲基）-巯基-4-（对甲苯基）-1,2,4-三唑-3-基）丁烷（MNP-14）和1,4-双（5-（乙氧基甲基））-硫基-4-（p -乙氧基苯基）-1,2,4-三唑-3-基）丁烷（MNP-16）。
4. Synthesis and investigation of 3,3'-bi-(5-trifluoromethyl-1,2,4-oxadiazole) and 5,5'-bi-(2- trifluoromethyl-1,3,4-oxadiazole) [C] . Marcos A. Kettner, Thomas M. Klapoetke, Tomasz G. Witkowski Seminar on New Trends in Research of Energetic Materials . 2016

机译：3,3'-双-（5-三氟甲基-1,2,4-恶二唑）和5,5'-双-（2-三氟甲基-1,3,4-恶二唑）的合成与研究
5. I. Synthesis of substituted naphthalenes utilizing active nickel. II. Synthesis of substituted naphthoquinones and formation of a charge transfer complex. III. Synthesis of substituted 1,4-diphenyl-2-butenes from (eta(6):eta(6)-1,4-diphenyl-1,3-butadiene)-bis(tricarbonylchromium) [D] . Forkner, Matthew W. 1988

机译：I.利用活性镍合成取代的萘。二。取代萘醌的合成和电荷转移配合物的形成。三，由（eta（6）：eta（6）-1,4-二苯基-1,3-丁二烯）-双（三羰基铬）合成取代的1,4-二苯基-2-丁烯
6. DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate) [O] . M. Broggini, J. A. Hartley, W. B. Mattes, 1980

机译：新型抗癌剂1,4-双（2'-氯乙基）-1,4-二氮杂双环-[2.2.1]庚烷二马来酸酯（马来酸达比斯）的DNA损伤和DNA结合的序列特异性
7. 5,5′-Diphenyl-2,2′-[butane-1,4-diylbis(sulfanediyl)]bis(1,3,4-oxadiazole) [O] . Wang, Wei, Qiu, Hong, Gao, Yan, 2010

机译：5,5'-联苯-2,2'-[丁烷-1,4-二基双（硫代二基）] bis（1,3,4-恶二唑）
8. Theoretical Prediction of the Heats of Formation, Densities and Relative Sensitivities, and/or Synthetic Approaches Toward the Synthesis of High Energy Dense Materials (HEDMs): 3,5-Dinitro-1,3,5-Oxadiazinane, Bis-Adjacent RDX, Bis-Adjacent HMX, 4,4',6,6'-Tetranitro-1,1'-Bis(N-oxide)-5,5',6,6'-4H,4'H-5,5'-Bisimidazo Oxadiazole, and the Open-Cage Derivative of CL-20. [R] . Byrd, E. F., Sabatini, J. J. 2015

机译：形成热，密度和相对灵敏度的理论预测，和/或合成高能量密集材料（HEDms）的合成方法：3,5-二硝基-1,3,5-恶二唑烷，双相邻RDX，Bis - 相邻的HmX，4,4'，6,6'-四硝基-1,1'-双（N-氧化物）-5,5'，6,6'-4H，4'H-5,5'-双咪唑恶二唑和CL-20的开笼衍生物。

Synthesis and cytotoxicity of bis-1,3,4-oxadiazoles and bis-pyrazoles derived from 1,4-bis(5-thio-4-substituted-1,2,4-triazol-3-yl)-butane and their DNA binding studies.

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