Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes.

Al Qahtani A; Siddiqui YM; Bekhit AA; El Sayed OA; Aboul Enein HY; Al Ahdalb MN

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Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes.

机译：吡唑并喹啉衍生物对杜氏利什曼原虫前鞭毛体生长的影响。

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A screening study was conducted to examine the effect of a series of synthesized pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes. Sixteen compounds were tested, ten of which showed an inhibitory effect on the growth of promastigotes. Compound 1 demonstrated potent antileishmanial activity, followed by compounds 3 and 7. Some compounds showed less significant activities, while others exhibited little or no activity. Some of these compounds may be potential candidates for future treatment of leishmaniasis.

机译：进行了筛选研究，以检验一系列合成的吡唑并喹啉衍生物对多形利什曼原虫前鞭毛体生长的影响。测试了16种化合物，其中10种对前鞭毛体的生长具有抑制作用。化合物1表现出有效的抗衰老活性，其次是化合物3和7。某些化合物显示的活性较低，而另一些则显示很少或没有活性。这些化合物中的某些可能是将来治疗利什曼病的潜在候选药物。

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来源
《Archiv der Pharmazie》 |2005年第10期|共4页
作者
Al Qahtani A; Siddiqui YM; Bekhit AA; El Sayed OA; Aboul Enein HY; Al Ahdalb MN;
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正文语种 eng
中图分类药学;
关键词
Antiprotozoal Agents; Leishmania donovani; Pyrazoles; Quinolines; 抗原虫药; 利什曼原虫; 杜氏; 吡唑类; 喹啉类;

机译：Antiprotozoal Agents;Leishmania donovani;Pyrazoles;Quinolines;抗原虫药;利什曼原虫;杜氏;吡唑类;喹啉类;

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专利

1. Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes. [J] . Al Qahtani A, Siddiqui YM, Bekhit AA, Archiv der Pharmazie . 2005,第10期

机译：吡唑并喹啉衍生物对杜氏利什曼原虫前鞭毛体生长的影响。
2. Iron enhances generation of free radicals by Artemisinin causing a caspase-independent, apoptotic death in Leishmania donovani promastigotes. [J] . Sen R, Saha P, Sarkar A, Free radical research . 2010,第11期

机译：铁可增强青蒿素的自由基生成，从而导致多毛利什曼原虫前鞭毛体中不依赖半胱天冬酶的凋亡性死亡。
3. In-vitro effects of Allopurinol - PALA combination on Leishmania donovani promastigotes. [J] . Sibaram Paria, Subhasis Maity, Musfiqua Mookerjee Biosciences Biotechnology Research Asia . 2009,第2期

机译：异嘌呤醇-PALA组合对杜氏利什曼原虫（Leishmania donovani）前鞭毛体的体外作用。
4. A study of a self diagnostic platform for the detection of A2 biomarker for Leishmania donovani [C] . Philip J. R. Roche, Maurice C. Cheung, Mohamed Najih, Optical diagnostics and sensing XII: toward point-of-care diagnosics; and Design and performance validation of phantoms used in conjunction with optical measurement of tissue IV. . 2012

机译：用于检测利什曼原虫A2生物标志物的自诊断平台的研究
5. Synthesis and use of 9-substituted adenine derivatives for studying Leishmania donovani 3'-nucleotidase. [D] . Szczepanik, Maciej Bernard. 2002

机译：9-取代的腺嘌呤衍生物的合成和用于研究利什曼原虫多诺万尼3'-核苷酸酶的用途。
6. Effects of an azasterol inhibitor of sterol 24-transmethylation on sterol biosynthesis and growth of Leishmania donovani promastigotes. [O] . P A Haughan, M L Chance, L J Goad 1995

机译：固醇24-甲基转移的氮杂固醇抑制剂对多形利什曼原虫前鞭毛体中固醇生物合成和生长的影响。
7. Effects of an azasterol inhibitor of sterol 24-transmethylation on sterol biosynthesis and growth of Leishmania donovani promastigotes. [O] . Haughan, P A, Chance, M L, Goad, L J 1995

机译：固醇24-甲基转移的氮杂甾醇抑制剂对多形利什曼原虫前鞭毛体中固醇生物合成和生长的影响。
8. Growth Cycle-Dependent Generation of Complement-Resistant Leishmania Promastigotes. [R] . Franke, E. D., McGreevy, P. B., Katz, S. P., 1985

机译：生长周期依赖的补体抗性利什曼原虫前鞭毛体的生成。

Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes.

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