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首页> 外文期刊>Archives of Andrology: An International Journal >Gonadal effect of radiation from 131I in male patients with thyroid carcinoma.
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Gonadal effect of radiation from 131I in male patients with thyroid carcinoma.

机译：131I辐射对男性甲状腺癌患者的性腺影响。

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摘要

The role of iodine-131 therapy in the management of differentiated thyroid carcinoma is well established. Because the spermatogonia are very sensitive to radiation, there is concern that large doses of the latter could result in azoospermia and permanent infertility. For patients treated with a single ablation dose, testicular function recovers within months and the risk of infertility is diminished. Gonadal damage may be cumulative in those requiring multiple administrations. In all young male patients, but especially in those with metastatic or pelvic disease or both, the long-term storage of semen should be addressed prior to therapy. Sperm banking should be considered in patients likely to be given cumulative doses greater than 14 GBq of 131I. However, the patient's threshold for sperm banking might be even lower than that.
机译：碘131治疗在分化型甲状腺癌的治疗中的作用已广为人知。由于精原细胞对辐射非常敏感，因此担心大剂量精子可能导致无精子症和永久性不育。对于接受单次消融剂量治疗的患者，睾丸功能可在数月内恢复，并且不孕风险降低。在需要多次给药的患者中，性腺损伤可能是累积性的。在所有年轻男性患者中，尤其是那些患有转移性或盆腔疾病或两者兼有的患者，应在治疗前解决精液的长期保存问题。对于可能获得大于131 I的14 GBq的累积剂量的患者，应考虑精子储存。但是，患者的精子库门槛可能甚至更低。

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