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首页> 外文期刊>Archives of Iranian medicine >Abdominal fat distribution and serum lipids in patients with and without coronary heart disease
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Abdominal fat distribution and serum lipids in patients with and without coronary heart disease

机译：患有和不患有冠心病的患者的腹部脂肪分布和血脂

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OBJECTIVE: To investigate the association between obesity indices, abdominal fat distribution, and lipid profile in patients with stable angina (SA). METHODS: Body weight, height, waist circumference (WC), body mass index (BMI), and waist /height ratio (WHtR) of 123 patients with SA who underwent coronary angiography were measured. Fasting blood samples were taken to measure the levels of fasting blood sugar (FBS), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), apolipoproteins A and B (apo A and apo B), and triglycerides (TG). According to angiography reports, the participants were divided into patients with or without coronary heart disease (CHD). All patients underwent an abdominal computerized tomography (CT) scan to measure the visceral, superficial, and deep subcutaneous fat. RESULTS: The mean ages of the patients with CHD (n = 73) and without CHD (n = 50) were 50.5 ?? 7.6 and 53.7 ?? 7.6 years, respectively (P = 0.03). The patients with CHD had significantly higher levels of TC, TG, and superficial subcutaneous fat, while the patients without CHD had higher levels of apo A (P ?? 0.05). Multivariate analyses showed a significant association of visceral fat with TC, LDL-C, TG, and apo B, in the patients without CHD, while significant inverse associations were found between WC and HDL-C, WHtR, and apo A as well as visceral fat and LDL-C in the patients with CHD. CONCLUSIONS: Among anthropometrics and imaging indices of obesity, WC and WHtR have shown better association between central obesity with dyslipidemia in the patients with CHD, while CT-measured visceral adipose tissue area was the best correlate of dyslipidemia in the patients without CHD.
机译：目的：探讨稳定型心绞痛（SA）患者的肥胖指数，腹部脂肪分布和血脂状况之间的关系。方法：测量了123例接受冠状动脉造影的SA患者的体重，身高，腰围（WC），体重指数（BMI）和腰围/身高比（WHtR）。抽取空腹血样以测量空腹血糖（FBS），总胆固醇（TC），低密度脂蛋白胆固醇和高密度脂蛋白胆固醇（LDL-C，HDL-C），载脂蛋白A和B（载脂蛋白A和载脂蛋白B）和甘油三酸酯（TG）。根据血管造影报告，参与者分为患有或不患有冠心病（CHD）的患者。所有患者均接受腹部计算机断层扫描（CT）扫描，以测量内脏，浅表和深层皮下脂肪。结果：患有冠心病的患者（n = 73）和没有冠心病的患者（n = 50）的平均年龄为50.5 ??。 7.6和53.7 ??分别为7.6年（P = 0.03）。冠心病患者的TC，TG和浅表皮下脂肪水平明显较高，而没有冠心病的患者的载脂蛋白A水平较高（P≥0.05）。多变量分析显示，在没有冠心病的患者中，内脏脂肪与TC，LDL-C，TG和apo B显着相关，而在WC与HDL-C，WHtR和apo A以及内脏之间发现显着的负相关冠心病患者的脂肪和LDL-C。结论：在肥胖症的人体测量学和影像学指标中，WC和WHtR在CHD患者中显示出中心性肥胖与血脂异常之间的相关性更好，而CT测量的内脏脂肪组织面积是非CHD患者血脂异常的最佳相关因素。

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