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首页> 外文期刊>Archives of cardiovascular diseases. Supplements >Non-valvular atrial fibrillation: Conventional antithrombotic treatments (vitamine K antagonists and antiplatelet agents) [Fibrillation atriale non valvulaire: Traitement antithrombotique conventionnel (antivitamines K et antiagrégants plaquettaires)]
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Non-valvular atrial fibrillation: Conventional antithrombotic treatments (vitamine K antagonists and antiplatelet agents) [Fibrillation atriale non valvulaire: Traitement antithrombotique conventionnel (antivitamines K et antiagrégants plaquettaires)]

机译：非瓣膜性房颤：常规抗血栓形成治疗（维生素K拮抗剂和抗血小板药）

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摘要

Antithrombotic treatments in patients with atrial fibrillation aim to prevent thromboembolic events, especially cerebral embolisms. The benefit of vitamin K antagonists (VKAs) has been widely demonstrated in randomized clinical trials. VKAs reduce the risk of stroke by approximately two-thirds. The absolute benefit of VKAs is increased in patients at high risk of thromboembolic events, including those with a history of ischaemic stroke or transient ischaemic attack. Yet, VKAs remain widely underused or misused. Among patients eligible for VKA treatment, only half receive VKAs. Many of those who are on VKAs are outside the therapeutic window most of the time and many patients stop treatment after a few years. The efficacy of aspirin in preventing thromboembolic events in patients is small or marginal and this treatment is also associated with bleeding complications. The combination of aspirin and clopidogrel is more efficacious than aspirin alone in preventing thromboembolic complications and should be preferred to aspirin in patients who have definite contraindications to oral anticoagulants.
机译：心房颤动患者的抗血栓治疗旨在预防血栓栓塞事件，尤其是脑栓塞。维生素K拮抗剂（VKA）的益处已在随机临床试验中得到广泛证明。 VKA可将中风的风险降低约三分之二。对于具有血栓栓塞事件高风险的患者，包括具有缺血性中风或短暂性脑缺血发作史的患者，VKA的绝对益处会增加。但是，VKA仍然被广泛使用或滥用。在符合VKA治疗条件的患者中，只有一半接受了VKA。很多使用VKA的人大部分时间都在治疗范围之外，并且许多患者在几年后停止治疗。阿司匹林预防患者血栓栓塞事件的功效很小或很小，而且这种治疗还伴有出血并发症。阿司匹林和氯吡格雷的组合在预防血栓栓塞性并发症方面比单独使用阿司匹林更有效，并且在口服抗凝剂有明确禁忌症的患者中，应优先于阿司匹林使用。

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