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首页> 外文期刊>Archives of Biochemistry and Biophysics >Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study
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Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study

机译：氨磷汀是一种放射防护剂，可保护大鼠脑组织脂质免受电离辐射诱发的损害：一项FTIR显微成像研究

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Amifostine is the only approved radioprotective agent by FDA for reducing the damaging effects of radiation on healthy tissues. In this study, the protective effect of amifostine against the damaging effects of ionizing radiation on the white matter (WM) and grey matter (GM) regions of the rat brain were investigated at molecular level. Sprague-Dawley rats, which were administered amifostine or not, were whole-body irradiated at a single dose of 800 cGy, decapitated after 24 h and the brain tissues of these rats were analyzed using Fourier transform infrared microspectroscopy (FTIRM). The results revealed that the total lipid content and CH _2 groups of lipids decreased significantly and the carbonyl esters, olefinicCH and CH _3 groups of lipids increased significantly in the WM and GM after exposure to ionizing radiation, which could be interpreted as a result of lipid peroxidation. These changes were more prominent in the WM of the brain. The administration of amifostine before ionizing radiation inhibited the radiation-induced lipid peroxidation in the brain. In addition, this study indicated that FTIRM provides a novel approach for monitoring ionizing radiation induced-lipid peroxidation and obtaining different molecular ratio images can be used as biomarkers to detect lipid peroxidation in biological systems.
机译：氨磷汀是FDA唯一批准的用于减少辐射对健康组织的破坏作用的放射防护剂。在这项研究中，从分子水平研究了氨磷汀对电离辐射对大鼠脑白质（WM）和灰质（GM）区域的破坏作用的保护作用。将未给予氨磷汀的Sprague-Dawley大鼠以800 cGy的单剂量全身照射，在24 h后断头，并使用傅立叶变换红外光谱法（FTIRM）分析这些大鼠的脑组织。结果表明，暴露于电离辐射后，WM和GM中脂质的总脂质含量和脂质中的CH _2基团显着降低，脂质的羰基酯，烯烃CH和CH _3基团显着增加，这可以解释为脂质的结果。过氧化。这些变化在大脑的WM中更为突出。电离辐射前给予氨磷汀抑制了辐射诱导的大脑脂质过氧化。此外，这项研究表明，FTIRM为监测电离辐射诱导的脂质过氧化提供了一种新颖的方法，并且获得不同的分子比图像可用作生物标记，以检测生物系统中的脂质过氧化。

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