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首页> 外文期刊>Archives of dermatological research. >Genetic association of IFN-γ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
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Genetic association of IFN-γ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

机译：药物诱导的史蒂文斯-约翰逊综合征/毒性表皮坏死症墨西哥患者中IFN-γ+ 874T / A多态性的遗传关联。

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Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, but potentially life-threatening diseases, characterized by widespread epidermal necrosis and are predominantly drug induced. There is a paucity of data regarding the role of cytokine and cytokine receptors polymorphisms in the pathoimmunology of SJS/TEN. The aim of this study was to investigate the role of TNF-α-308, IFN-γ +874, IL-10-1082, IL-13 Arg130Gln, and IL-4R Gln551Arg gene polymorphisms in SJS/TEN in Mexican Mestizo patients. Twenty-nine unrelated SJS/TEN patients and 128 unrelated healthy individuals were studied. Genomic extraction was carried out from complete blood samples using the salting out method. The PCR-RFLP method was used to amplify the following polymorphisms: TNF-α-308, IFN-γ +874, IL-10-1082, IL-13 Arg130Gln, and IL-4R Gln551Arg. TNF-α-308, IL-10-1082, IL-13 Arg130Gln, and IL-4R Gln551Arg polymorphisms were not associated with the genetic susceptibility to SJS/TEN. The distribution of TT, TA, AA genotypes of IFN-γ +874 was significantly different in SJS/TEN patients compared with controls (pC = 0.012). TA and AA genotypes were grouped to highlight the differences between patients and controls given by the absence of the AA genotype in the group of patients (pC = 0.03, OR = 3.61 95 % CI 1.20-11.6). This preliminary study suggests that IFN-γ +874 T/A polymorphism is associated with SJS/TEN.
机译：史蒂文斯-约翰逊综合征/中毒性表皮坏死症（SJS / TEN）罕见，但具有潜在的威胁生命的疾病，其特征是广泛的表皮坏死，并且主要是药物诱导的。关于细胞因子和细胞因子受体多态性在SJS / TEN的病理免疫中的作用的数据很少。这项研究的目的是调查墨西哥Mestizo患者SJS / TEN中TNF-α-308，IFN-γ+ 874，IL-10-1082，IL-13 Arg130Gln和IL-4R Gln551Arg基因多态性的作用。研究了29名无关的SJS / TEN患者和128名无关的健康个体。使用盐析法从全血样品中提取基因组。 PCR-RFLP方法用于扩增以下多态性：TNF-α-308，IFN-γ+ 874，IL-10-1082，IL-13 Arg130Gln和IL-4R Gln551Arg。 TNF-α-308，IL-10-1082，IL-13 Arg130Gln和IL-4R Gln551Arg多态性与SJS / TEN的遗传易感性无关。与对照组相比，SJS / TEN患者的IFN-γ+874 TT，TA，AA基因型分布明显不同（pC = 0.012）。将TA和AA基因型分组以突出显示患者与对照组之间的差异，这是由于患者组中缺乏AA基因型所致（pC = 0.03，OR = 3.61 95％CI 1.20-11.6）。这项初步研究表明，IFN-γ+874 T / A多态性与SJS / TEN有关。

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