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首页> 外文期刊>Archives of dermatological research. >Genetic association of IFN-γ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
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Genetic association of IFN-γ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

机译：IFN-γ+ 874T /墨西哥药物诱导史蒂文森综合征/有毒表皮患者多态性的IFN-γ+ 874T /多态性。

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摘要

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, but potentially life-threatening diseases, characterized by widespread epidermal necrosis and are predominantly drug induced. There is a paucity of data regarding the role of cytokine and cytokine receptors polymorphisms in the pathoimmunology of SJS/TEN. The aim of this study was to investigate the role of TNF-α-308, IFN-γ +874, IL-10-1082, IL-13 Arg130Gln, and IL-4R Gln551Arg gene polymorphisms in SJS/TEN in Mexican Mestizo patients. Twenty-nine unrelated SJS/TEN patients and 128 unrelated healthy individuals were studied. Genomic extraction was carried out from complete blood samples using the salting out method. The PCR-RFLP method was used to amplify the following polymorphisms: TNF-α-308, IFN-γ +874, IL-10-1082, IL-13 Arg130Gln, and IL-4R Gln551Arg. TNF-α-308, IL-10-1082, IL-13 Arg130Gln, and IL-4R Gln551Arg polymorphisms were not associated with the genetic susceptibility to SJS/TEN. The distribution of TT, TA, AA genotypes of IFN-γ +874 was significantly different in SJS/TEN patients compared with controls (pC = 0.012). TA and AA genotypes were grouped to highlight the differences between patients and controls given by the absence of the AA genotype in the group of patients (pC = 0.03, OR = 3.61 95 % CI 1.20-11.6). This preliminary study suggests that IFN-γ +874 T/A polymorphism is associated with SJS/TEN.
机译：史蒂文斯 - 约翰逊综合征/有毒表皮坏死（SJ / Ten）是罕见的，但潜在的危及生命的疾病，其特征是普遍的表皮坏死，主要是药物诱导。缺乏关于细胞因子和细胞因子受体多态性在SJ / Ten的病理过程中的作用的数据。本研究的目的是探讨TNF-α-308，IFN-γ+874，IL-10-1082，IL-13 ARG130GLN和IL-4R GLN551ARG基因多态性在墨西哥Mestizo患者中的作用。研究了二十九个无关的SJS / 10名患者和128名无关的健康个体。基因组萃取从使用盐洗法从完全血液样品中进行。使用PCR-RFLP方法扩增以下多态性：TNF-α-308，IFN-γ+874，IL-10-1082，IL-13 ARG130GLN和IL-4R GLN551ARG。 TNF-α-308，IL-10-1082，IL-13 ARG130GLN和IL-4R GLN551ARG多态性与SJ / T1的遗传易感性无关。与对照相比，SJS / 10患者的IFN-γ+874的TT，TA，AA基因型的分布显着不同（PC = 0.012）。分组Ta和AA基因型以突出通过患者组中没有AA基因型的患者和对照组的差异（PC = 0.03，或= 3.61 95％CI 1.20-11.6）。该初步研究表明IFN-γ+874 T / A多态性与SJS / Ten相关联。

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