Prevalence and Clinical Significance of FLT3 Mutation Status in Acute Myeloid Leukemia Patients: A Multicenter Study

Cuervo-Sierra Jorge; Carlos Jaime-Perez Jose; Martinez-Hernandez Ramon A.; Garcia-Sepulveda Ricardo D.; Sanchez-Cardenas Monica; Gomez-Almaguer David; Ortiz-Lopez Rocio; Villarreal-Villarreal Cesar D.; Ruiz-Arguelles Guillermo J.; Ruiz-Delgado Guillermo; Lutz-Presno Julia; Garces-Eisele Javier; Ignacio-Ibarra Gregorio; Mucino-Hernandez Gabriel; Arana-Trejo Rosa M.; Jimenez-Mejia Angelica M.; Vasquez-Palacio Gonzalo

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Prevalence and Clinical Significance of FLT3 Mutation Status in Acute Myeloid Leukemia Patients: A Multicenter Study

机译：急性髓细胞性白血病患者FLT3突变状态的患病率及其临床意义：一项多中心研究

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Background and Aims. FLT3-ITD mutations in acute myeloid leukemia (AML) are associated with a poor prognosis. In Latin America, little epidemiological data exist about these mutations and their influence on clinical evolution and prognosis. Standardization and well established clinical correlation make FLT3 mutational analysis by molecular methods an invaluable tool to decide among treatment options and to determine AML prognosis.

机译：背景和目标。急性髓细胞性白血病（AML）中的FLT3-ITD突变与不良预后相关。在拉丁美洲，关于这些突变及其对临床进化和预后的影响的流行病学数据很少。标准化和行之有效的临床相关性使得通过分子方法进行FLT3突变分析成为决定治疗方案和确定AML预后的宝贵工具。

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《Archives of medical research》 |2016年第3期|共8页
作者
Cuervo-Sierra Jorge; Carlos Jaime-Perez Jose; Martinez-Hernandez Ramon A.; Garcia-Sepulveda Ricardo D.; Sanchez-Cardenas Monica; Gomez-Almaguer David; Ortiz-Lopez Rocio; Villarreal-Villarreal Cesar D.; Ruiz-Arguelles Guillermo J.; Ruiz-Delgado Guillermo; Lutz-Presno Julia; Garces-Eisele Javier; Ignacio-Ibarra Gregorio; Mucino-Hernandez Gabriel; Arana-Trejo Rosa M.; Jimenez-Mejia Angelica M.; Vasquez-Palacio Gonzalo;
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正文语种 eng
中图分类医药、卫生;
关键词
Acute myeloid leukemia; AML; FLT3; Latin America;

机译：急性髓细胞白血病;AML;FLT3;拉丁美洲;

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1. Prevalence and Clinical Significance of FLT3 Mutation Status in Acute Myeloid Leukemia Patients: A Multicenter Study [J] . Cuervo-Sierra Jorge, Carlos Jaime-Perez Jose, Martinez-Hernandez Ramon A., Archives of medical research . 2016,第3期

机译：急性髓细胞性白血病患者FLT3突变状态的患病率及其临床意义：一项多中心研究
2. The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. [J] . Green CL, Evans CM, Hills RK, Blood: The Journal of the American Society of Hematology . 2010,第15期

机译：IDH1突变在急性髓样白血病的年轻成人患者中的预后意义取决于FLT3 / ITD状态。
3. Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. [J] . Green CL, Koo KK, Hills RK, Journal of Clinical Oncology . 2010,第16期

机译：CEBPA突变在一大批年轻的急性髓性白血病患者中的预后意义：双重CEBPA突变的影响以及与FLT3和NPM1突变的相互作用。
4. A Metadata-Based Patient Register for Cooperative Clinical Research: A Case Study in Acute Myeloid Leukemia [C] . Anja S. FISCHER, Ulrich MANSMANN Medical Informatics in Europe Conference. . 2011

机译：基于元数据的合作临床研究患者注册：急性髓性白血病案例研究
5. Pharmacology Profiles of ALK and FLT3 Kinase Inhibitors against Non-Small-Cell Lung Cancer Cells and Acute Myeloid Leukemia Cells with Cancer Driver Mutations [D] . 森政道 2019

机译：ALK和FLT3激酶抑制剂对非小细胞肺癌细胞和急性髓系白血病细胞的癌症驱动突变的药理作用
6. Correspondence: Response: Conflicting data on the prognostic significance of FLT3-TKD mutations in cytogenetically normal acute myeloid leukemia (CN-AML) might be related to many factors including techniques used to detect FLT3-TKD differences in patient populations studied and treatment regimens [O] . Susan P. Whitman, Guido Marcucci, Amy S. Ruppert, -1

机译：对应：响应：关于细胞遗传学上正常的急性髓性白血病（CN-AML）中FLT3-TKD突变对预后意义的数据矛盾可能与许多因素有关包括用于检测FLT3-TKD的技术所研究患者人群的差异以及治疗方法养生
7. Response: Conflicting data on the prognostic significance of FLT3-TKD mutations in cytogenetically normal acute myeloid leukemia (CN-AML) might be related to many factors, including techniques used to detect FLT3-TKD, differences in patient populations studied, and treatment regimens [O] . Whitman, Susan P., Marcucci, Guido, Ruppert, Amy S., 2008

机译：回答：关于细胞遗传学上正常的急性髓性白血病（CN-AML）中FLT3-TKD突变的预后意义的数据冲突可能与许多因素有关，包括用于检测FLT3-TKD的技术，所研究患者人群的差异以及治疗方案

Prevalence and Clinical Significance of FLT3 Mutation Status in Acute Myeloid Leukemia Patients: A Multicenter Study

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