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首页> 外文期刊>Archives of dermatological research. >Sirtuins in dermatology: applications for future research and therapeutics.
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Sirtuins in dermatology: applications for future research and therapeutics.

机译：Sirtuins在皮肤病学中的应用：用于未来的研究和治疗。

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摘要

Sirtuins are a family of seven proteins in humans (SIRT1-SIRT7) that are involved in multiple cellular processes relevant to dermatology. The role of sirtuins in other organ systems is established. However, the importance of these proteins in dermatology is less defined. Recently, sirtuins gained international attention because of their role as "longevity proteins" that may extend and enhance human life. Sirtuins function in the cell via histone deacetylase and/or adenosine diphosphate ribosyltransferase enzymatic activity that target histone and non-histone substrates, including transcription regulators, tumor suppressors, structural proteins, DNA repair proteins, cell signaling proteins, transport proteins, and enzymes. Sirtuins are involved in cellular pathways related to skin structure and function, including aging, ultraviolet-induced photoaging, inflammation, epigenetics, cancer, and a variety of cellular functions including cell cycle, DNA repair and proliferation. This review highlights sirtuin-related cellular pathways, therapeutics and pharmacological targets in atopic dermatitis, bullous dermatoses, collagen vascular disorders, psoriasis, systemic lupus erythematosus, hypertrophic and keloid scars, cutaneous infections, and non-melanoma and melanoma skin cancer. Also discussed is the role of sirtuins in the following genodermatoses: ataxia telangiectasia, Cowden's syndrome, dyskeratosis congenita, Rubenstein-Taybi, Werner syndrome, and xeroderma pigmentosum. The pathophysiology of these inherited diseases is not well understood, and sirtuin-related processes represent potential therapeutic targets for diseases lacking suitable alternative treatments. The goal of this review is to bring attention to the dermatology community, physicians, and scientists, the importance of sirtuins in dermatology and provide a foundation and impetus for future discussion, research and pharmacologic discovery.
机译：Sirtuins是人体内的七个蛋白质家族（SIRT1-SIRT7），涉及与皮肤病学相关的多个细胞过程。 sirtuins在其他器官系统中的作用已确定。但是，这些蛋白质在皮肤病学中的重要性尚不清楚。最近，sirtuins由于其作为“长寿蛋白”的作用而受到国际关注，这些蛋白可以延长并改善人类的生活。 Sirtuins通过组蛋白脱乙酰基酶和/或腺苷二磷酸核糖基转移酶在细胞中的功能，该酶活性靶向组蛋白和非组蛋白底物，包括转录调节剂，肿瘤抑制子，结构蛋白，DNA修复蛋白，细胞信号蛋白，转运蛋白和酶。 Sirtuins参与与皮肤结构和功能有关的细胞途径，包括衰老，紫外线诱导的光老化，炎症，表观遗传学，癌症以及多种细胞功能，包括细胞周期，DNA修复和增殖。这篇综述重点介绍了特应性皮炎，大疱性皮肤病，胶原蛋白血管疾病，牛皮癣，系统性红斑狼疮，肥厚性和瘢痕loid疤痕，皮肤感染，非黑色素瘤和黑色素瘤皮肤癌中与瑟土因相关的细胞途径，治疗方法和药理学目标。还讨论了沉默调节蛋白在以下皮肤病中的作用：共济失调性毛细血管扩张症，考登氏综合症，先天性角化病，鲁本斯坦-塔比，韦纳氏综合症和色素干性皮肤病。这些遗传性疾病的病理生理学尚未得到很好的理解，而瑟土因相关的过程代表了缺乏适当替代疗法的疾病的潜在治疗靶标。这篇综述的目的是引起皮肤病学界，医师和科学家的注意，瑟土因在皮肤病学中的重要性，并为将来的讨论，研究和药理发现提供基础和动力。

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