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首页> 外文期刊>Archives of disease in childhood >Lung function and respiratory health in adolescents of very low birth weight.
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Lung function and respiratory health in adolescents of very low birth weight.

机译：出生体重很低的青少年的肺功能和呼吸健康。

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AIMS: To determine if very low birth weight (VLBW; birth weight <1500 g) is associated with reduced lung function and respiratory health in adolescence and, if it is, whether this impairment is associated with prematurity or intrauterine growth restriction. METHODS: A geographically defined cohort of 128 VLBW infants and an age, sex, and school matched comparison group born in 1980/81 were studied. The cohort and comparison group were assessed at 15 years of age. The birth weight ratio of the index cases (observed birth weight/expected birth weight for the gestation) was determined to assess the degree of growth restriction. Respiratory support received during the neonatal period was obtained from hospital records. Smoking habits and respiratory morbidity were obtained through questionnaires. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and forced expiratory flow when 25-75% of FVC is expired (FEF(25-75%)) were measured using a portable spirometer. The values are expressed as percentage predicted for height, age, and gender using standard reference values. Adjustments were made for smoking habits of mother and children. RESULTS: The differences in means between index and comparison groups for FEF(25-75%) (-12.42%; p < 0.001) and FEV1/FVC (-3.53%; p < 0.001) ratio were statistically significant. The differences in FVC and FEV1 were not significant. No correlation was found between the birth weight ratio and lung function among the index cohort. Chronic cough, wheezing, and asthma were more common among the index cohort than in the comparison group. Within the index group, there was no difference in lung function between those who received and those who did not receive respiratory support. CONCLUSION: Adolescents who were VLBW compared with matched controls showed medium and small airways obstruction. This was associated with prematurity rather than intrauterine growth restriction or having received respiratory support during the neonatal period. The index VLBW cohort compared with their controls were also more prone to chronic cough, wheezing, and asthma.
机译：目的：确定极低的出生体重（VLBW;出生体重<1500 g）是否与青春期肺功能下降和呼吸系统健康有关，以及是否与早产或子宫内生长受限有关。方法：研究了128个VLBW婴儿的地理区域队列，以及1980/81年出生的年龄，性别和学校匹配的比较组。队列和比较组在15岁时进行评估。确定指标病例的出生体重比（观察的出生体重/妊娠的预期出生体重）以评估生长受限的程度。新生儿期间获得的呼吸支持来自医院记录。吸烟习惯和呼吸系统疾病通过问卷调查获得。使用便携式肺活量计测量了强制肺活量（FVC），1秒内的强制呼气量（FEV1）和FVC的25-75％到期时的强制呼气流量（FEF（25-75％））。这些值表示为使用标准参考值预测的身高，年龄和性别的百分比。调整了母亲和儿童的吸烟习惯。结果：FEF（25-75％）（-12.42％; p <0.001）和FEV1 / FVC（-3.53％; p <0.001）比率在指标组和对照组之间的均值差异具有统计学意义。 FVC和FEV1的差异不明显。在该指数队列中，出生体重比与肺功能之间没有相关性。与对照组相比，在该指标队列中慢性咳嗽，喘息和哮喘更为常见。在该指标组内，接受和未接受呼吸支持者之间的肺功能没有差异。结论：与配对对照组相比，VLBW青少年表现出中，小气道阻塞。这与早产有关，而不是宫内生长受限或在新生儿期已获得呼吸支持。与对照组相比，VLBW队列指数也更容易出现慢性咳嗽，喘息和哮喘。

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