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首页> 外文期刊>Archives of dermatological research. >Tissue viability imaging (TiVi) in the assessment of divergent beam UV-B provocation.
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Tissue viability imaging (TiVi) in the assessment of divergent beam UV-B provocation.

机译：组织生存力成像（TiVi）用于评估发散光束UV-B激发。

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In routine clinical phototesting and in basic research, naked eye dermatological assessment is the "gold standard" for determining the patient's minimal erythemal dose (MED). In UV-B testing with a divergent, radially attenuating beam of characterised dosimetry, laser Doppler perfusion imaging has been previously used to give quantitative description of reactivity to doses above the MED in addition to a "single-dose" objective determination of the MED itself. In the present paper, the recently developed tissue viability imaging (TiVi) technology is presented for the first time as a reliable, easily applicable, high-resolution alternative to LDPI in the divergent beam testing concept. Data obtained after provocation with a range of doses was analysed in order to determine the reaction diameter, which can be related to the MED using field dosimetry. The dose-response features of exposure above the MED and the relationship between naked eye readings and the diameter were determined from the image data. TiVi data were obtained faster than LDPI data and at a higher spatial resolution of 100 mum instead of 1 mm. A tool was developed to centre over the erythema area of the acquired image. Response data could be plotted continuously against dose. Thresholding of processed images compared to naked eye "gold standard" readings showed that the normal skin value +4 standard deviations produced a good fit between both methods. A linear fitting method for the dose-response data provided a further method of determination of the reaction diameter (MED). Erythemal volume under the surface (VUS) visualising information. TiVi offers advantages over LDPI in the acquisition and analysis of data collected during divergent beam testing. An increased amount of data compared to traditional phototesting is easily and more objectively obtained which increases applicability in the clinical and research environment.
机译：在常规的临床光测试和基础研究中，裸眼皮肤病学评估是确定患者最小红斑剂量（MED）的“金标准”。在具有特征剂量学的发散的，径向衰减的光束的UV-B测试中，除了对MED本身进行“单剂量”客观测定以外，以前已经使用激光多普勒灌注成像对MED以上的剂量进行了反应性的定量描述。 。在本文中，首次提出了最近开发的组织生存力成像（TiVi）技术，作为发散束测试概念中LDPI的可靠，易于应用的高分辨率替代品。分析激发后在一定剂量范围内获得的数据，以确定反应直径，这可以与使用现场剂量测定法的MED有关。从图像数据确定MED上方的曝光剂量响应特征以及裸眼读数与直径之间的关系。 TiVi数据比LDPI数据更快地获得，并且具有100毫米而不是1毫米的更高空间分辨率。开发了一种工具来将获取的图像的红斑区域居中。反应数据可以相对于剂量连续绘制。与裸眼“金标准”读数相比，处理后图像的阈值显示正常皮肤值+4标准偏差在两种方法之间产生了很好的契合度。剂量反应数据的线性拟合方法提供了另一种确定反应直径（MED）的方法。表面下的红斑体积（VUS）可视化信息。在散束测试期间采集和分析数据方面，TiVi优于LDPI。与传统的光测试相比，可以轻松，客观地获得更多的数据，从而增加了在临床和研究环境中的适用性。

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