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首页> 外文期刊>Archives of dermatological research. >Mechanosignaling pathways in cutaneous scarring
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Mechanosignaling pathways in cutaneous scarring

机译：皮肤瘢痕形成中的机械信号通路

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摘要

Mechanotransduction is the process by which physical forces are sensed and converted into biochemical signals that then result in cellular responses. The discovery and development of various molecular pathways involved in this process have revolutionized the fundamental and clinical understanding regarding the formation and progression of cutaneous scars. The aim of this review is to report the recent advances in scar mechanosignaling research. The mechanosignaling pathways that participate in the formation and growth of cutaneous scars can be divided into those whose role in mechanoresponsiveness has been proven (the TGF-β/Smad, integrin, and calcium ion pathways) and those who have a possible but as yet unproven role (such as MAPK and G protein, Wnt/βcatenin, TNF-α/NF-κB, and interleukins). During scar development, these cellular mechanosignaling pathways interact actively with the extracellular matrix. They also crosstalk extensively with the hypoxia, inflammation, and angiogenesis pathways. The elucidation of scar mechanosignaling pathways provides a new platform for understanding scar development. This better understanding will facilitate research into this promising field and may help to promote the development of pharmacological interventions that could ultimately prevent, reduce, or even reverse scar formation or progression.
机译：机械转导是感测物理力并将其转换为生化信号，然后导致细胞反应的过程。在此过程中涉及的各种分子途径的发现和发展彻底改变了有关皮肤疤痕形成和发展的基本和临床理解。这篇综述的目的是报告疤痕机械信号研究的最新进展。参与皮肤疤痕形成和生长的机械信号传递途径可分为那些已被证实在机械反应性中起作用的途径（TGF-β/ Smad，整联蛋白和钙离子途径）和那些可能但尚未得到证实的途径。作用（例如MAPK和G蛋白，Wnt /βcatenin，TNF-α/NF-κB和白介素）。在疤痕形成过程中，这些细胞机械信号通路与细胞外基质积极相互作用。它们还与缺氧，炎症和血管生成途径广泛串扰。疤痕机械信号通路的阐明为理解疤痕的发展提供了新的平台。这种更好的理解将有助于对这一有前途的领域的研究，并可能有助于促进可能最终预防，减少甚至逆转疤痕形成或进展的药理学干预措施的发展。

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