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首页> 外文期刊>Archives of dermatological research. >Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?
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Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?

机译：人原发性皮肤黑素瘤中趋化因子受体CXCR4，CCR7，CCR9和CCR10的过表达：CCR7和CCR10的潜在预后价值？

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摘要

Multiple functional implications have been suggested for a limited number of chemokines and their cognate receptors in melanoma pathogenesis. The purpose of this study was to investigate the potential role of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 as prognostic markers in human primary cutaneous melanoma. Chemokine receptor expression was analyzed by immunohistochemistry in a total of 38 patients with cutaneous melanoma. Results were statistically correlated with melanoma features and clinical disease progression. No significant correlation between overexpression of CXCR4 or CCR9 and survival or prognosis was found. CCR7 overexpression was associated with significantly lower survival (0.005 log rank) and shorter time to progression (0.009 log rank)-similar to CCR10 overexpression (lower survival: 0.001 log rank, shorter time to progression: 0.002 log rank). In addition, CCR7 overexpression correlated with expression of metallothionein, while CCR10 seems to be associated with cerebral metastases. Two chemokine receptors permitting the identification of high-risk patients were identified: CCR7 and CCR10 overexpressions were found to be associated with a worse outcome of disease course independent of Breslow's tumor thickness and Clark level, thus representing possible additional prognostic markers.
机译：对于黑色素瘤发病机理中趋化因子及其同源受体的数量有限，已经提出了多种功能含义。这项研究的目的是调查趋化因子受体CXCR4，CCR7，CCR9和CCR10作为人类原发性皮肤黑色素瘤的预后标志物的潜在作用。通过免疫组织化学分析了总共38例皮肤黑色素瘤患者的趋化因子受体表达。结果与黑素瘤特征和临床疾病进展在统计学上相关。 CXCR4或CCR9的过表达与生存或预后之间无显着相关性。与CCR10过表达类似（CCR10过表达（较低的生存期：0.001 log等级，较短的进展时间：0.002 log等级）），CCR7过表达与较低的生存期（0.005 log等级）和较短的进展时间（0.009 log等级）相关。另外，CCR7的过表达与金属硫蛋白的表达有关，而CCR10似乎与脑转移有关。确定了两种可以识别高危患者的趋化因子受体：发现CCR7和CCR10过表达与病程恶化有关，而与Breslow的肿瘤厚度和Clark水平无关，从而代表了可能的其他预后指标。

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