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首页> 外文期刊>Archives of dermatological research. >Pathophysiology of generalized pustular psoriasis.
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Pathophysiology of generalized pustular psoriasis.

机译：全身脓疱型牛皮癣的病理生理学。

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Generalized pustular psoriasis (GPP) is a serious dermatological disease characterized by fever, chills, rigors, and generalized pustule formation on the skin. Previous analyses in Japan have led to the proposal to divide GPP into two groups, one with a history of ordinary psoriasis (pso(+) GPP) and the other without a history of psoriasis (pso(-) GPP). Clinically the onset of the pustular outbreak is earlier in pso(-) GPP, which occurs more frequently after infections, whereas pso(+) GPP occurs more frequently following corticosteroid therapy. Substantial differences are also noted in HLA analyses. Activation of neutrophils is a basic mechanism in both types of GPP. Although the epidermal structural changes in GPP are usually not so prominent as those in psoriasis vulgaris, pso(+) GPP shows a more psoriasiform architecture than pso(-) GPP. Analysis of epidermal cell proliferation in GPP indicates that it is not less than that seen in psoriasis vulgaris. The occasional psoriasiform epidermal architecture especially seen in pso(+) GPP may be considered to be a steady-state condition achieved after epidermal cell proliferation has continued for a sustained period. Various inflammatory cytokines appear to be involved in the neutrophilic infiltrate seen in GPP.
机译：广义脓疱性牛皮癣（GPP）是一种严重的皮肤病，其特征是发烧，发冷，严酷和在皮肤上形成脓疱。日本以前的分析导致提出将GPP分为两类的提议，一组具有普通牛皮癣的病史（pso（+）GPP），另一组没有牛皮癣的病史（pso（-）GPP）。临床上脓疱性发作的发生在pso（-）GPP中更早，在感染后更频繁发生，而pso（+）GPP在皮质类固醇治疗后更频繁地发生。 HLA分析中也指出了实质性差异。中性粒细胞的激活是两种GPP中的基本机制。尽管GPP中的表皮结构变化通常不如寻常型牛皮癣显着，但pso（+）GPP比pso（-）GPP显示出更多的牛皮癣状结构。对GPP中表皮细胞增殖的分析表明，它不少于寻常型牛皮癣。特别是在pso（+）GPP中看到的偶尔的牛皮癣状表皮结构可以认为是在表皮细胞增殖持续持续一段时间后达到的稳态状态。 GPP中出现的嗜中性浸润似乎与多种炎性细胞因子有关。

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