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首页> 外文期刊>Archives of disease in childhood. Fetal and neonatal edition >Improving head growth in preterm infants--a randomised controlled trial II: MRI and developmental outcomes in the first year.
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Improving head growth in preterm infants--a randomised controlled trial II: MRI and developmental outcomes in the first year.

机译：改善早产儿的头部生长-一项随机对照试验II：第一年的MRI和发育结果。

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BACKGROUND: Very preterm infants are at risk of poor growth and neurodevelopmental outcome. Illness and difficulties overcoming the challenges of feeding these infants often lead to undernutrition in the first few weeks. OBJECTIVE: To explore the relationships between early nutrition, post-natal head growth, quantitative magnetic resonance imaging (MRI) and developmental outcome in the first year among infants born before 29 weeks' gestation. DESIGN: Infants born before 29 weeks' gestation were randomised to receive hyperalimented or standard feeding regimen from birth to 34 weeks' postmenstrual age (PMA). The primary outcome was occipitofrontal circumference (OFC) at 36 weeks' OFC. Quantitative MRI was performed at 40 weeks' PMA. Developmental assessment using Bayley Scales of Infant Development II (BSID II) was carried out at 3 and 9 months post-term. RESULTS: 109 infants survived to the end of the first year PMA. 65 infants underwent MRI scan. 81 and 71 infants were seen at 3 and 9 months post-term.Quantitative MRI findings, mental development index (MDI) and psychomotor development index (PDI) were not statistically different between the two groups. Total brain volume (TBV) at 40 weeks' PMA, MDI and PDI at 3 months post-term correlated significantly with energy deficit at 28 days of age CONCLUSIONS: Improving early energy deficit in very preterm infants may promote brain growth. Quantitative MRI may have a role to play in predicting developmental outcome. Post-natal growth at 36 weeks' PMA and quantitative MRI finding at 40 weeks' PMA appear to be closely related to mental outcomes in the first year. TRIAL REGISTRATION NUMBER: ISRCTN 19509258.
机译：背景：早产儿有生长不良和神经发育结局的风险。疾病和困难克服了喂养这些婴儿的挑战，通常会在头几周导致营养不良。目的：探讨妊娠29周之前出生的婴儿第一年的早期营养，出生后头部生长，定量磁共振成像（MRI）与发育结果之间的关系。设计：将在妊娠29周之前出生的婴儿从出生至月经后34周（PMA）随机接受高营养或标准喂养方案。主要结果是OFC在36周的OFC时发生。在40周PMA时进行定量MRI。足月后3个月和9个月使用贝利婴儿发育量表II（BSID II）进行发育评估。结果：109名婴儿存活至第一年PMA。 65例婴儿接受了MRI扫描。足月3个月和9个月时分别观察到81例和71例婴儿。两组的MRI定量检查，智力发育指数（MDI）和精神运动发育指数（PDI）差异无统计学意义。足月后3个月PMA，MDI和PDI在40周时的总脑容量（TBV）与28日龄时的能量缺乏显着相关。结论：改善早产儿的早期能量缺乏可能会促进大脑生长。定量MRI可能在预测发育结果中起作用。在第一年，PMA在36周时的产后生长和PMA在40周时的定量MRI发现似乎与心理结果密切相关。试用注册号：ISRCTN 19509258。

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