• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of disease in childhood. Fetal and neonatal edition >Value of a single C-reactive protein measurement at 18 h of age
【24h】

Value of a single C-reactive protein measurement at 18 h of age

机译：18小时龄时进行单一C反应蛋白测量的价值

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To evaluate the usefulness of a single C-Reactive Protein (CRP) measurement at 18 h of age to identify neonates where antibiotics started for possible early onset sepsis (EOS) could safely be discontinued. Design/Methods In a prospective cohort of 647 preterm (<35 weeks) and 555 late preterm (35-36 weeks) or term newborns with maternal and/or neonatal risk factors for EOS, CRP levels were measured between 15 and 21 h of age. Results: There were 16, 107 and 1079 neonates with proven EOS, possible EOS and no EOS, respectively. Among the 645 neonates with a CRP<10 mg/L, 1 had proven EOS, 43 had possible EOS and 601 (93.2%) were not infected. All with possible or proven EOS were either less than 35 weeks' gestation, symptomatic at the time of CRP assessment or remained on antibiotics because of maternal bacteraemia: they would therefore not be considered for discharge. There were 557 neonates with a 18-h CRP≥ 10 mg/L. Of these, 15 had proven EOS, 64 had possible EOS, and 478 (85.8%) were not infected. Sensitivity and specificity of 18-h CRP for proven or possible EOS were 64% (95% CI 56 to 73) and 56% (95% CI 53 to 59), respectively. The negative predictive value was 93% (95% CI 91 to 95), and the positive predictive value was 14% (95% CI 11 to 17). Conclusions: The duration of antibiotic treatment in neonates born beyond 34 weeks' gestation and asymptomatic at the time of CRP assessment could be potentially reduced with a diagnostic algorithm that includes a point-of-care 18-h CRP measurement. An elevated 18-h CRP in isolation should not be used as a reason to prolong antibiotics.
机译：目的：评估18岁以下单次C反应蛋白（CRP）的有效性，以鉴定可以安全地中止可能因早发性败血症（EOS）开始使用抗生素的新生儿。设计/方法在647例早产儿（<35周）和555例早产儿（35-36周）或具有母亲和/或新生儿EOS危险因素的足月新生儿的前瞻性队列中，在15至21 h年龄之间测量了CRP水平。结果：分别有16例107例和1079例EOS被证实，可能的EOS和没有EOS的新生儿。在CRP <10 mg / L的645例新生儿中，有1例已证明EOS，43例可能有EOS，并且601例（93.2％）未感染。所有可能或已证实的EOS都小于妊娠35周，在进行CRP评估时有症状，或者由于母体菌血症而继续使用抗生素：因此，不考虑将其排出。有557名新生儿的18小时CRP≥10 mg / L。其中15个已证明EOS，64个可能已EOS，并且478个（85.8％）未感染。 18h CRP对已证实或可能的EOS的敏感性和特异性分别为64％（95％CI 56至73）和56％（95％CI 53至59）。阴性预测值为93％（95％CI 91到95），阳性预测值为14％（95％CI 11-17）。结论：通过包括18小时即时CRP测量的诊断算法，可以潜在地减少妊娠超过34周且CRP评估时无症状的新生儿的抗生素治疗时间。不应将升高的18小时CRP用作延长抗生素的理由。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号