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The preterm infant with thrombosis.

机译:早产儿有血栓形成。

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摘要

In paediatrics, sick preterm infants are at highest risk of developing thrombotic complications. Haemostasis is in a fine balance in the neonatal period, despite age-related differences in coagulation proteins. However, both inherited and acquired risk factors can disrupt this balance and can lead to thrombosis. Important risk factors are sepsis, asphyxia, dehydration, central venous lines and inherited and acquired thrombophilia. Among various treatment modalities, anticoagulation is primarily used in the management of thrombosis. Different agents, dosages and durations of treatment in this age group are extrapolated from adult data. The article reviews the epidemiology, pathophysiology, risk factors, diagnosis and treatment of thrombotic disorders in preterm infants.
机译:在儿科中,患病的早产儿发生血栓形成并发症的风险最高。尽管凝血蛋白存在与年龄相关的差异,但新生儿的止血效果良好。但是,遗传和后天的危险因素都可能破坏这种平衡,并导致血栓形成。重要的危险因素是败血症,窒息,脱水,中心静脉血栓以及遗传性和获得性血栓形成。在各种治疗方式中,抗凝剂主要用于血栓形成的管理。从成人数据推断出该年龄组中不同的药物,剂量和治疗时间。本文回顾了早产儿血栓形成疾病的流行病学,病理生理学,危险因素,诊断和治疗。

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