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首页> 外文期刊>BMJ: British medical journal >Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study
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Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study

机译：发展的预测微蛋白尿和macroalbuminuria 1型患者糖尿病:《盗梦空间》队列研究

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Objective To evaluate baseline predictors for the development of persistent microalbuminuria and macroalbuminuria prospectively in patients with type 1 diabetes. Design Prospective observational study of an inception cohort. Setting Outpatient diabetic clinic in a tertiary referral centre, Gentofte, Denmark. Participants 286 patients (216 adults) newly diagnosed with type 1 diabetes consecutively admitted to the clinic between 1 September 1979 and 31 August 1984. Main outcome measures Persistent microalbuminuria and persistent macroalbuminuria. Results During the median follow up of 18.0 years (range 1.0-21.5 years), total of 4706 patient years of follow up, 79 of 277 patients developed persistent microalbuminuria. 27 progressed further to persistent macroalbuminuria. The cumulative incidence of persistent microalbuminuria and persistent macroalbuminuria was 33.6% (95% confidence interval 27.2% to 40.0%) and 14.6% (8.9% to 20.3%), respectively. Significant predictors (95% confidence intervals) for the development of persistent microalbuminuria were a 10-fold increase in urinary albumin excretion rate (relative risk 3.78, 1.57 to 9.13), being male (2.41, 1.43 to 4.06), a 10 mm Hg increase in mean arterial blood pressure (1.38, 1.20 to 1.57), a 1% increase in haemoglobin A_(1c) (1.18, 1.04 to 1.32), and a 1 cm increase in height (0.96, 0.95 to 0.98). 28 patients with microalbuminuria (35%) regressed to normoalbuminuria either transiently (n = 15) or permanently (n = 13). Conclusions Around one third of patients newly diagnosed with type 1 diabetes develop persistent microalbuminuria within the first 20 years of diabetes. Several potentially modifiable risk factors predict the development of persistent microalbuminuria and persistent macroalbuminuria
机译：摘要目的评估基线预测持续的微蛋白尿和发展macroalbuminuria患者的前瞻性1型糖尿病。《盗梦空间》的研究群体。糖尿病诊所三级转诊中心,根措夫特,丹麦。成年人)新诊断为1型糖尿病1之间的连续送进诊所1979年9月和1984年8月31日。持续的微蛋白尿和措施持久macroalbuminuria。平均随访18.0年(范围1.0 - -21.5年),共有4706个病人年的跟进,79年的277例持续发展微蛋白尿。持久macroalbuminuria。持续的微蛋白尿和发生率持久macroalbuminuria (95% 33.6%置信区间)27.2%到40.0%和14.6%分别(8.9%对20.3%)。预测(95%置信区间)发展持久微蛋白尿是一个尿白蛋白排泄增加10倍率(相对危险度3.78,1.57到9.13)男性(2.41,1.43,4.06),增加10毫米汞柱平均动脉血压(1.38、1.201.57),血红蛋白增加1%现代(1 c) (1.18,1.04到1.32),增加1厘米的高度(0.96, 0.95, 0.98)。微量白蛋白尿(35%)退化normoalbuminuria瞬变(n = 15)或永久(n = 13)。三分之一的患者新诊断为1型糖尿病发展持续微蛋白尿在第一个20年的糖尿病。预测潜在的可改变的危险因素持续的微蛋白尿和发展持久macroalbuminuria

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