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首页> 外文期刊>Applied optics >Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters
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Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters

机译：用组织模拟剂量计检查脉冲光与连续波光的吸收光动力剂量

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A dosimetric system has been developed to measure the spatially resolved light dose absorbed by a photosensitizer in a tissue-simulating medium. These gelatin-based dosimeters had macroscopic optical scattering and absorption properties that are typical for homogeneous tissue and contained the photosensitizer benzoporphyrin derivative monoacid (BPD-MA). A reporter molecule, 2'7'-dichlorofluorescin diacetate (DCF-DA), served as an actinometer, which could be photosensitized by BPD-MA to generate a highly fluorescent photoproduct. The relative photosensitizing efficiencies of high-intensity pulsed and cw laser light were compared in these tissue-simulating dosimeters. These measurements demonstrate an increase in penetration for pulsed light as compared with cw light in the dosimeters. A numerical simulation of the light propagation based on optical diffusion theory was used along with the energy levels of the photosensitizer molecule to examine the mechanisms involved in the absorbed dose. The increased penetration of high-intensity pulsed light was due to a transient decrease in the absorption of the photosensitizer, resulting from saturation of the photosensitizer optical transitions. This study provides the first direct comparison of the photodynamic dose absorbed by a photosensitizer using both high-intensity pulsed and cw laser light in a tissue-simulating medium. These measurements demonstrate that a small increase in depth &treatment is possible with pulsed laser light as compared with cw laser light simply on the basis of the unique photochemistry of the photosensitizer. However, this effect still needs to be examined carefully in tumor tissue, where other biological or chemical effects may become significant. # 1997 Optical Society of America
机译：已经开发出剂量测定系统以测量在组织模拟介质中光敏剂吸收的空间分辨的光剂量。这些基于明胶的剂量计具有均匀的组织通常具有的宏观光学散射和吸收特性，并且包含光敏剂苯并卟啉衍生物单酸（BPD-MA）。报告分子2'7'-二氯荧光素二乙酸酯（DCF-DA）用作光度计，可以被BPD-MA光敏化以生成高度荧光的光产物。在这些组织模拟剂量计中比较了高强度脉冲和连续激光的相对光敏效率。这些测量结果表明，与剂量计中的连续光相比，脉冲光的穿透力有所提高。基于光扩散理论的光传播数值模拟与光敏剂分子的能级一起用于检查吸收剂量所涉及的机理。高强度脉冲光的穿透性增加是由于光敏剂光学跃迁的饱和导致光敏剂吸收的瞬时降低。这项研究提供了在组织模拟介质中使用高强度脉冲激光和连续激光的光敏剂吸收的光动力剂量的首次直接比较。这些测量结果表明，仅基于光敏剂的独特光化学，与连续波激光相比，脉冲激光可能会稍微增加深度和处理量。但是，仍然需要在肿瘤组织中仔细检查这种作用，而其他生物学或化学作用可能会变得很重要。 ＃1997美国眼镜学会

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