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首页> 外文期刊>Applied optics >Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors
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Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors

机译：光剂量法和组织间隙光动力疗法联合治疗大块肿瘤的系统的可行性研究

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A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared. (C) 2002 Optical Society of America. [References: 24]
机译：描述了用于光动力激光治疗大块肿瘤的系统，该系统采用将多根光纤插入到肿瘤块中。通过肿瘤的光通量可以通过使用单独的光纤作为发射器和接收器来评估。利用描述扩散光传播的计算机模型，光学剂量测定法正在开发中。已经在实验动物肿瘤模型中对该系统进行了测试，以准备进行临床工作。目前，δ-氨基乙酰丙酸被用作敏化剂，由2.0W紧凑型二极管激光系统发出的635nm辐射激活。随着未来的可用性，吸收约750 nm的高选择性药物，应可治疗更大的肿瘤，周围的敏感正常组织也应避免。 （C）2002年美国眼镜学会。 [参考：24]

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