Significance of TP53 Mutation in Cellular Process and Disease Progression in Lung Adenocarcinoma

Yongbo Hou; Sheng Tan; Guoxiang Wang

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Significance of TP53 Mutation in Cellular Process and Disease Progression in Lung Adenocarcinoma

机译：TP53突变细胞过程的意义并在肺腺癌疾病进展

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Introduction:TP53 (tumor protein p53) is one of the most commonly mutanted genes in lung adenocarcinoma (LUAD).Materials and Methods: In this study, we used data from The Cancer Genome Atlas (TCGA) to evaluate the importance of TP53 mutations in cellular processes, disease progression, the prognosis in LUAD, and to identify critical hub genes and pathways associated with oncogenesis.Results: Analysis of the TCGA data showed TP53 mutations in 22% of LUAD patients. Clinicopathological analyses demonstrated that TP53 mutation was correlated with the disease progression but not prognosis. We identified 1935 differentially expressed genes (DEGs). Functional enrichment analysis showed that the DEGs were mainly concentrated in metabolism, cell differentiation, and cancer-related pathways. The top hub genes were identified and disease analysis revealed the most critical genes related to disease progression and prognosis. The expression levels of several of these genes were then tested in tumor tissues.Conclusion: Our results showed that TP53 mutation plays a critical role in cellular process and the clinicopathological findings in LUAD. We also identified potential key genes, which could provide novel evidence for individualized treatment.

机译：作品简介:TP53(肿瘤蛋白质p53)就是其中之一最常见的突变基因在肺腺癌(LUAD)。这项研究中,我们使用癌症基因组的数据(TCGA)评估TP53的重要性突变细胞过程,疾病在LUAD进展、预后,识别关键基因和通路中心与肿瘤形成有关。TCGA的数据显示,22%的TP53突变LUAD病人。证明了TP53突变相关随着疾病进展而不是预后。我们确定了1935个差异表达基因(度)。度主要是集中在代谢、细胞分化和癌症相关的通路。识别和疾病分析显示最多疾病进展和相关的关键基因预后。这些基因在肿瘤进行测试组织。在细胞变异起着至关重要的作用过程和临床病理的研究LUAD。这可能提供新颖的证据吗个性化的治疗。

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《Genetic testing and molecular biomarkers》 |2021年第5期|346-354|共9页
作者
Yongbo Hou; Sheng Tan; Guoxiang Wang;
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作者单位

Department of Cardio-Thoracic Surgery, Xuzhou Medical College Affiliated Hospital;

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原文格式 PDF
正文语种英语
中图分类遗传学;
关键词
Adenocarcinoma of lung; Disease Progression; Tumor Suppressor Protein p53Cellular processesRNA SequenceAnalyses, SequenceMutationGenes;

机译：肺腺癌;疾病进展;肿瘤抑制蛋白质p53Cellular processesRNASequenceAnalyses, SequenceMutationGenes;

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Significance of TP53 Mutation in Cellular Process and Disease Progression in Lung Adenocarcinoma

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