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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Behavioural changes induced by a conditional disruption of bone formation
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Behavioural changes induced by a conditional disruption of bone formation

机译：行为改变诱导条件破坏骨形成

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Background: It has been shown that the brain regulates bone remodelling through sympathetic and parasympa-thetic nerve fibres. However, it is unclear if signals from the skeleton also influence brain functions and animal behaviours. Methods: Bone formation was conditionally disrupted by daily injections of aciclovir (10 mg/kg) to transgenic mice expressing a herpes-simplex-virus thymidine kinase under the control of the osteoblast-specific promoter of the Bglap gene. Behavioural studies were conducted after 10 weeks of treatment. Results: Transgenic mice receiving aciclovir injections showed a reduced number of osteoblasts with a concomi-tantly reduced trabecular bone volume density, when compared to wild-type controls that were treated identically. The general health of the animals was not severely affected, as indicated by a similar increase in body weight, similar activity profiles and similar social behaviours. However, transgenic mice showed significantly increased despair behaviour and increased adrenal gland weights. Conclusions: Specific animal behaviours can be modulated by a selective disruption of bone formation. The increased despair behaviour observed in transgenic animals indicates that these animals may be more prone to depression-related phenotypes. These findings are important in the context of the well-established clinical association between depression and reduced bone mass.
机译：背景:已经表明,大脑通过交感神经调节骨重建和parasympa-thetic神经纤维。如果信号的骨架也不清楚影响大脑功能和动物行为。方法:对骨形成是有条件的每天注射阿昔洛韦(10而中断毫克/公斤)转基因小鼠表达单纯疱疹病毒胸苷激酶下osteoblast-specific启动子的控制Bglap基因。治疗10周后进行。转基因小鼠接受注射阿昔洛韦显示减少了成骨细胞的数量concomi-tantly骨小梁体积减少密度,与野生型相比控件治疗相同。动物没有受到严重影响,所示类似的增加体重,类似的活动概要文件和类似的社会行为。显著增加行为和绝望肾上腺重量增加。特定的动物行为可以调制选择性破坏骨形成。增加的绝望行为中观察到转基因动物表明这些动物可能更容易抑郁症表型。完善临床抑郁和降低骨之间的联系质量。

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